Low J A, Galbraith R S, Muir D W, Killen H L, Pater E A, Karchmar E J
Am J Obstet Gynecol. 1983 Apr 15;145(8):1059-68. doi: 10.1016/0002-9378(83)90867-0.
Two hundred forty-two high-risk children and 47 low-risk children were prospectively studied to assess the relationship between biologic risk factors that occurred during the perinatal period and the motor and cognitive deficits that were identified during the first year of life. Multiple risk factors were present in 80% of the children of the high-risk group. Provisional deficits were classified on the degree of abnormality found in a clinical and behavioral assessment that included neurological examinations, Bayley Physical and Mental Development Scales, and the Uzgiris and Hunt Scale. Provisional deficits occurred in 10% of the children of the low-risk group. High-risk children had a significantly greater incidence of provisional deficits, particularly in respect to positive deficits. In high-risk children, the probability of a deficit was 17% in those without infection or encephalopathy, 30% in those with infection, and 40% in those with encephalopathy.
对242名高危儿童和47名低危儿童进行了前瞻性研究，以评估围产期出现的生物学危险因素与出生后第一年发现的运动和认知缺陷之间的关系。高危组80%的儿童存在多种危险因素。根据临床和行为评估中发现的异常程度对临时缺陷进行分类，评估包括神经学检查、贝利身体和智力发育量表以及乌兹吉里斯和亨特量表。低危组10%的儿童出现临时缺陷。高危儿童出现临时缺陷的发生率显著更高，尤其是阳性缺陷。在高危儿童中，无感染或脑病的儿童出现缺陷的概率为17%，有感染的儿童为30%，有脑病的儿童为40%。
