82Rb 的人体生物分布和辐射剂量学。
Human biodistribution and radiation dosimetry of 82Rb.
机构信息
Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA.
出版信息
J Nucl Med. 2010 Oct;51(10):1592-9. doi: 10.2967/jnumed.110.077669. Epub 2010 Sep 16.
UNLABELLED
Prior estimates of radiation-absorbed doses from (82)Rb, a frequently used PET perfusion tracer, yielded discrepant results. We reevaluated (82)Rb dosimetry using human in vivo biokinetic measurements.
METHODS
Ten healthy volunteers underwent dynamic PET/CT (6 contiguous table positions, each with separate (82)Rb infusion). Source organ volumes of interest were delineated on the CT images and transferred to the PET images to obtain time-integrated activity coefficients. Radiation doses were estimated using OLINDA/EXM 1.0.
RESULTS
The highest mean absorbed organ doses (μGy/MBq) were observed for the kidneys (5.81), heart wall (3.86), and lungs (2.96). Mean effective doses were 1.11 ± 0.22 and 1.26 ± 0.20 μSv/MBq using the tissue-weighting factors of the International Commission on Radiological Protection (ICRP), publications 60 and 103, respectively.
CONCLUSION
Our current (82)Rb dosimetry suggests reasonably low radiation exposure. On the basis of this study, a clinical (82)Rb injection of 2 × 1,480 MBq (80 mCi) would result in a mean effective dose of 3.7 mSv using the weighting factors of the ICRP 103-only slightly above the average annual natural background exposure in the United States (3.1 mSv).
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先前对（82）Rb 的辐射吸收剂量的估计值，（82）Rb 是一种常用于 PET 灌注示踪剂的元素，得到了不一致的结果。我们使用人体体内生物动力学测量重新评估了（82）Rb 的剂量测定。
方法
十名健康志愿者接受了动态 PET/CT（6 个连续的体位，每个体位都有单独的（82）Rb 输注）。在 CT 图像上划定感兴趣的源器官体积，并将其转移到 PET 图像上以获得时间积分的活性系数。使用 OLINDA/EXM 1.0 估计辐射剂量。
结果
观察到最高的平均吸收器官剂量（μGy/MBq）为肾脏（5.81）、心脏壁（3.86）和肺部（2.96）。使用国际辐射防护委员会（ICRP）的组织权重因子 60 和 103，平均有效剂量分别为 1.11 ± 0.22 和 1.26 ± 0.20 μSv/MBq。
结论
我们目前的（82）Rb 剂量测定值表明辐射暴露相当低。根据这项研究，使用 ICRP 103 仅加权因子的临床（82）Rb 注射 2×1480 MBq（80 mCi）将导致平均有效剂量为 3.7 mSv，略高于美国的平均年自然背景暴露量（3.1 mSv）。
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