State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, 430073 Wuhan, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
Int J Biol Macromol. 2024 Apr;263(Pt 2):130333. doi: 10.1016/j.ijbiomac.2024.130333. Epub 2024 Feb 24.
The cystic cavity that develops following spinal cord injury is a major obstacle for repairing spinal cord injury (SCI). The injectable self-healing biomaterials treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury. Herein, a natural extracellular matrix (ECM) biopolymer hyaluronic acid-based hydrogel was developed based on multiple dynamic covalent bonds. The hydrogels exhibited excellent injectable and self-healing properties, could be effectively injected into the injury site, and filled the lesion cavity to accelerate the tissue repair of traumatic SCI. Moreover, the hydrogels were compatible with cells and various tissues and possessed proper stiffness matched with nervous tissue. Additionally, when implanted into the injured spinal cord site, the hyaluronic acid-based hydrogel promoted axonal regeneration and functional recovery by accelerating remyelination, axon regeneration, and angiogenesis. Overall, the injectable self-healing hyaluronic acid-based hydrogels are ideal biomaterials for treating traumatic SCI.
脊髓损伤后形成的囊腔是修复脊髓损伤（SCI）的主要障碍。可注射自修复生物材料治疗是增强创伤性脊髓损伤后组织修复的有前途的策略。在此，基于多种动态共价键，开发了一种天然细胞外基质（ECM）生物聚合物透明质酸水凝胶。水凝胶表现出优异的可注射和自修复特性，可以有效注入损伤部位，并填充病变腔，以加速创伤性 SCI 的组织修复。此外，水凝胶与细胞和各种组织相容，并且具有与神经组织相匹配的适当刚度。此外，当植入损伤的脊髓部位时，透明质酸水凝胶通过加速髓鞘再生、轴突再生和血管生成来促进轴突再生和功能恢复。总体而言，可注射自修复透明质酸水凝胶是治疗创伤性 SCI 的理想生物材料。
