Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Strasse 8, 35039, Marburg, Germany.
Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Hans-Meerwein-Strasse 6, 35032, Marburg, Germany.
Sci Rep. 2024 Feb 26;14(1):4632. doi: 10.1038/s41598-024-54660-2.
The brain can adapt its expectations about the relative timing of actions and their sensory outcomes in a process known as temporal recalibration. This might occur as the recalibration of timing between the sensory (e.g. visual) outcome and (1) the motor act (sensorimotor) or (2) tactile/proprioceptive information (inter-sensory). This fMRI recalibration study investigated sensorimotor contributions to temporal recalibration by comparing active and passive conditions. Subjects were repeatedly exposed to delayed (150 ms) or undelayed visual stimuli, triggered by active or passive button presses. Recalibration effects were tested in delay detection tasks, including visual and auditory outcomes. We showed that both modalities were affected by visual recalibration. However, an active advantage was observed only in visual conditions. Recalibration was generally associated with the left cerebellum (lobules IV, V and vermis) while action related activation (active > passive) occurred in the right middle/superior frontal gyri during adaptation and test phases. Recalibration transfer from vision to audition was related to action specific activations in the cingulate cortex, the angular gyrus and left inferior frontal gyrus. Our data provide new insights in sensorimotor contributions to temporal recalibration via the middle/superior frontal gyri and inter-sensory contributions mediated by the cerebellum.
大脑可以通过时间校准过程来调整其对动作相对时间及其感觉结果的预期。这种调整可能发生在感觉（例如视觉）结果与（1）运动行为（感觉运动）或（2）触觉/本体感觉信息（感觉间）之间的时间校准。这项 fMRI 校准研究通过比较主动和被动条件来研究感觉运动对时间校准的贡献。受试者反复接受延迟（150 毫秒）或非延迟视觉刺激，由主动或被动按钮按下触发。在延迟检测任务中测试了校准效果，包括视觉和听觉结果。我们表明，两种模态都受到视觉校准的影响。然而，仅在视觉条件下观察到主动优势。校准通常与左小脑（小叶 IV、V 和蚓部）有关，而在适应和测试阶段，与动作相关的激活（主动>被动）发生在右侧中/上额回。从视觉到听觉的校准转移与扣带皮层、角回和左额下回的动作特异性激活有关。我们的数据通过中/上额回为时间校准的感觉运动贡献提供了新的见解，并通过小脑介导的感觉间贡献提供了新的见解。
