Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, People's Republic of China.
Child Care Health Dev. 2024 Mar;50(2):e13237. doi: 10.1111/cch.13237.
This meta-analysis evaluated the relationship between overweight/obesity and depressive disorders in children and adolescents.
We examined the databases of PubMed, Embase and Web of Science for pertinent observational studies released up until 20 February 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) of obesity and overweight with depressive disorder were calculated by means of random-effects models. The Newcastle-Ottawa Quality Assessment Scale and Agency for Healthcare Research and Quality scale were adopted to evaluate the study quality.
Finally, for this meta-analysis, we evaluated 22 observational publications covering 175 135 participants (5 cohort study articles, 1 case-control study article and 16 cross-sectional study articles). A significant positive association was found between obesity and the risk of depression (RR 1.32, 95% CI 1.09-1.60, I = 79.90%, P < 0.001) and in the association between obesity and depressive symptoms (RR 1.16, 95% CI: 1.00-1.35, I = 25.0%, P = 0.247). On sensitivity analysis, the pooled RRs remained robust. Subgroup analysis indicated that obese children and teenagers in western countries were more prone to depression.
Evidence from this meta-analysis, based on observational studies, supported the idea that obese children and adolescents are more likely to experience depression and depressive symptoms.
本荟萃分析评估了超重/肥胖与儿童和青少年抑郁障碍之间的关系。
我们检索了 PubMed、Embase 和 Web of Science 数据库，以获取截至 2022 年 2 月 20 日发布的相关观察性研究。采用随机效应模型计算肥胖和超重与抑郁障碍的合并相对风险（RR）和 95%置信区间（CI）。采用纽卡斯尔-渥太华质量评估量表和医疗保健研究与质量局量表评估研究质量。
最终，本荟萃分析评估了 22 项观察性研究出版物，涵盖了 175135 名参与者（5 篇队列研究文章、1 篇病例对照研究文章和 16 篇横断面研究文章）。肥胖与抑郁风险（RR 1.32，95%CI 1.09-1.60，I²=79.90%，P<0.001）和肥胖与抑郁症状之间存在显著正相关（RR 1.16，95%CI：1.00-1.35，I²=25.0%，P=0.247）。敏感性分析结果表明，合并 RR 仍然稳健。亚组分析表明，西方国家的肥胖儿童和青少年更容易患抑郁症。
基于观察性研究的本荟萃分析结果支持肥胖儿童和青少年更有可能经历抑郁和抑郁症状的观点。
