肥胖增加儿童和青少年患抑郁症的风险：一项系统评价和荟萃分析的结果。

Obesity increases the risk of depression in children and adolescents: Results from a systematic review and meta-analysis.

作者信息

Rao Wen-Wang, Zong Qian-Qian, Zhang Ji-Wen, An Feng-Rong, Jackson Todd, Ungvari Gabor S, Xiang Yifan, Su Ying-Ying, D'Arcy Carl, Xiang Yu-Tao

机构信息

Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China; Center for Cognition and Brain Sciences, University of Macau, Macao SAR, China.

School of Nursing, Capital Medical University, Beijing, China; The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

出版信息

J Affect Disord. 2020 Apr 15;267:78-85. doi: 10.1016/j.jad.2020.01.154. Epub 2020 Jan 27.

DOI:10.1016/j.jad.2020.01.154

PMID:32063576

Abstract

BACKGROUND

Clinical depression (including major depression, dysthymia, and unspecified depression) is common in children and adolescents with obesity and overweight. The objective of this systematic review and meta-analysis was to examine prevalence of clinical depression among overweight and obese children.

METHODS

PubMed, EMBASE, Web of Science, Medline, Cochrane library, and PsycINFO databases were systematically and independently searched by three researchers from the inception dates to April 01, 2019. The fixed-effects model was used to perform meta-analysis. Data analyses were performed with STATA Version 12.0.

RESULTS

Eleven studies with 69,893 subjects were included; 5 studies examined major depressive disorder (MDD), while the remaining 6 studies examined other types of clinical depression. In the overweight and obese group, the prevalence of clinical depression ranged from 1.7% to 26.7% in obese subjects and from 4.0% to 16.9% in overweight subjects. In studies on MDD, prevalence ranged from 10.1% to 26.7% in obese subjects and from 9.0% to 16.9% in overweight subjects. The odd ratios (ORs) of clinical depression ranged from 0.92 to 4.39 between obese subjects and healthy controls (i.e., normal-weight controls), and ranged from 0.96 to 1.67 between overweight subjects and controls. Compared to healthy controls, obese (OR = 1.851, 95% CI: 1.410-2.429) but not overweight (OR = 1.068, 95% CI: 0.889-1.283) children and adolescents were more likely to have MDD.

CONCLUSION

Obese children and adolescents had a significantly higher risk for MDD compared with healthy controls. Considering the negative health outcomes of depression, regular screening and effective treatments should be implemented for obese children and adolescents.

摘要

背景

临床抑郁症（包括重度抑郁症、心境恶劣障碍和未特定的抑郁症）在肥胖和超重的儿童及青少年中很常见。本系统评价和荟萃分析的目的是研究超重和肥胖儿童中临床抑郁症的患病率。

方法

三名研究人员从各数据库创建日期至2019年4月1日，对PubMed、EMBASE、科学网、Medline、Cochrane图书馆和PsycINFO数据库进行了系统且独立的检索。采用固定效应模型进行荟萃分析。数据分析使用STATA 12.0版软件。

结果

纳入了11项研究，共69,893名受试者；5项研究考察了重度抑郁症（MDD）,其余6项研究考察了其他类型的临床抑郁症。在超重和肥胖组中，肥胖受试者的临床抑郁症患病率在1.7%至26.7%之间，超重受试者的患病率在4.0%至16.9%之间。在关于MDD的研究中，肥胖受试者的患病率在10.1%至26.7%之间，超重受试者的患病率在9.0%至16.9%之间。肥胖受试者与健康对照（即正常体重对照）之间临床抑郁症的比值比（OR）在0.92至4.39之间，超重受试者与对照之间的比值比在0.96至1.67之间。与健康对照相比，肥胖儿童和青少年（OR = 1.851，95%CI：1.410 - 2.429）而非超重儿童和青少年（OR = 1.068，95%CI：0.889 - 1.283）更易患MDD。