Clark Grayson P, Caldwell Haley M, Coop Christopher A, Neaves Brittanie I, Barnes Peter W
Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA.
Internal Medicine, Keesler Medical Center, Biloxi, USA.
Cureus. 2024 Jan 26;16(1):e53011. doi: 10.7759/cureus.53011. eCollection 2024 Jan.
Fixed drug eruption (FDE) is a cutaneous reaction that characteristically recurs in the same locations upon re-exposure to the offending drug(s). The typical presentation of FDEs is single or multiple violaceous plaques with hyperpigmentation due to inflammation. The causative agents for FDEs include antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, barbiturates, and anticonvulsants. We present an interesting case of a generalized fixed drug eruption secondary to cefepime that resolved with the cessation of the offending drug and the institution of antihistamines and topical steroids.
固定性药疹（FDE）是一种皮肤反应，其特征是再次接触致病药物时会在相同部位复发。FDE的典型表现是单个或多个紫罗兰色斑块，并伴有炎症引起的色素沉着。FDE的致病因素包括抗生素、非甾体抗炎药（NSAIDs）、对乙酰氨基酚、巴比妥类药物和抗惊厥药。我们报告了一例有趣的病例，该病例为头孢吡肟继发的全身性固定性药疹，停用致病药物并使用抗组胺药和外用类固醇后病情得到缓解。
