Mahboob A, Haroon T S
Department of Dermatology, King Edward Medical College/Mayo Hospital, Lahore, Pakistan.
Int J Dermatol. 1998 Nov;37(11):833-8. doi: 10.1046/j.1365-4362.1998.00451.x.
Drug eruptions are among the most common cutaneous disorders encountered by the dermatologist. Some drug eruptions, although trivial, may cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The diagnostic hallmark is its recurrence at previously affected sites.
We evaluated 450 FDE patients to determine the causative drugs.
The ratio of men to women was 1:1.1. The main presentation of FDE was circular hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema, urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally FDE mimicked lichen planus, erythema multiforme, Stevens-Johnson syndrome, paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen planus actinicus, discoid lupus erythematosus, erythema annulare centrifugum, pemphigus vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis. Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid, mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, allopurinol, orphenadrine, and albendazole.
Cotrimoxazole was the most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel pamoate, clindamycin, and albendazole were reported for the first time. FDE may have multiform presentations.
药疹是皮肤科医生最常遇到的皮肤疾病之一。有些药疹虽然轻微，但可能会造成外观上的困扰，固定性药疹（FDE）就是其中之一。其诊断特征是在先前受累部位复发。
我们评估了450例固定性药疹患者以确定致病药物。
男女比例为1:1.1。固定性药疹的主要表现为圆形色素沉着过度性损害。较少见的表现为：无色素沉着的红斑、荨麻疹、皮炎、眶周或全身性色素沉着过度。偶尔，固定性药疹类似扁平苔藓、多形红斑、史蒂文斯-约翰逊综合征、甲沟炎、唇炎、银屑病、主妇皮炎、黄褐斑、光化性扁平苔藓、盘状红斑狼疮、离心性环状红斑、寻常型天疱疮、冻疮、玫瑰糠疹以及外阴或肛周色素沉着过度。复方新诺明是固定性药疹最常见的病因。其他有嫌疑的药物包括四环素、安乃近、保泰松、对乙酰氨基酚、乙酰水杨酸、甲芬那酸、甲硝唑、替硝唑、氯美扎酮、阿莫西林、氨苄西林、红霉素、颠茄、灰黄霉素、苯巴比妥、双氯芬酸钠、吲哚美辛、布洛芬、二氟尼柳、双羟萘酸噻嘧啶、克林霉素、别嘌醇、奥芬那君以及阿苯达唑。
复方新诺明是固定性药疹最常见的病因，而双氯芬酸钠、双羟萘酸噻嘧啶、克林霉素和阿苯达唑所致的固定性药疹为首次报道。固定性药疹可能有多种表现形式。
