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剩余病理标本的储存、留存及利用:被低估的宝藏

Storage, Retention, and Use of Leftover Pathology Specimens: The Underestimated Treasures.

作者信息

Begum N Fazulunnisa, Ramalingam Karthikeyan, Ramani Pratibha

机构信息

Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

出版信息

Cureus. 2024 Jan 26;16(1):e53025. doi: 10.7759/cureus.53025. eCollection 2024 Jan.

DOI:10.7759/cureus.53025
PMID:38410328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10895552/
Abstract

The proper regulations for storage, retention, and use of archived specimens in pathology laboratories and academic institutions are yet to be established. These specimens could be used appropriately for research purposes. Ideal storage and retention in a controlled environment is necessary, and there is a lack of established rules regarding the ownership of the tissue specimens, paraffin blocks, and slides. Though there are numerous uses of formalin-fixed tissue specimens, blocks, and slides, there are also problems in archiving them that hinder their use. This review article addresses the above issues and proposes simple guidelines for the effective use of archived specimens.

摘要

病理学实验室和学术机构中存档标本的妥善存储、保存和使用的适当规定尚未确立。这些标本可适当地用于研究目的。在受控环境中进行理想的存储和保存是必要的,而且关于组织标本、石蜡块和载玻片的所有权缺乏既定规则。尽管福尔马林固定的组织标本、石蜡块和载玻片有多种用途,但在存档时也存在阻碍其使用的问题。这篇综述文章探讨了上述问题,并提出了有效使用存档标本的简单指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d60/10895552/03dd809a6065/cureus-0016-00000053025-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d60/10895552/03dd809a6065/cureus-0016-00000053025-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d60/10895552/03dd809a6065/cureus-0016-00000053025-i01.jpg

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本文引用的文献

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Ethical issues in the use of leftover samples and associated personal data obtained from diagnostic laboratories.从诊断实验室获取的剩余样本及相关个人资料的使用所涉及的伦理问题。
Clin Chim Acta. 2023 Aug 1;548:117442. doi: 10.1016/j.cca.2023.117442. Epub 2023 Jun 10.
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Potential values of formalin-fixed paraffin-embedded tissues for intratumoral microbiome analysis in breast cancer.福尔马林固定石蜡包埋组织在乳腺癌瘤内微生物组分析中的潜在价值。
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Impact of a centralized archive for pathology laboratories on the health system.
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累及颊黏膜的口腔丛状神经纤维瘤:病例报告
Cureus. 2024 Sep 30;16(9):e70514. doi: 10.7759/cureus.70514. eCollection 2024 Sep.
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Arch Pathol Lab Med. 2021 Feb 1;145(2):222-226. doi: 10.5858/arpa.2019-0474-OA.
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Evaluation of the Use of Formalin-Fixed and Paraffin-Embedded Archive Gastric Tissues for Microbiota Characterization Using Next-Generation Sequencing.利用下一代测序技术评估福尔马林固定石蜡包埋存档胃组织用于微生物组特征分析的效果。
Int J Mol Sci. 2020 Feb 7;21(3):1096. doi: 10.3390/ijms21031096.
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