Krishnamurthy Savitri
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Cytopathol. 2015 Mar;123(3):152-61. doi: 10.1002/cncy.21505. Epub 2014 Dec 18.
Biospecimen repositories are important for the advancement of biomedical research. Literature on the potential for biobanking of fine-needle aspiration, gynecologic, and nongynecologic cytology specimens is very limited. The potential for biobanking of these specimens as valuable additional resources to surgically excised tissues appears to be excellent. The cervicovaginal specimens that can be used for biobanking include Papanicolaou-stained monolayer preparations and residual material from liquid-based cytology preparations. Different types of specimen preparations of fine-needle aspiration and nongynecologic specimens, including Papanicolaou-stained and Diff-Quik-stained smears, cell blocks. and dedicated passes/residual material from fine-needle aspiration stored frozen in a variety of solutions, can be used for biobanking. Because of several gaps in knowledge regarding the standard of operative procedures for the procurement, storage, and quality assessment of cytology specimens, further studies as well as national conferences and workshops are needed not only to create awareness but also to facilitate the use of cytopathology specimens for biobanking.
生物样本库对于生物医学研究的进展至关重要。关于细针穿刺、妇科和非妇科细胞学标本生物样本库潜力的文献非常有限。将这些标本作为手术切除组织的宝贵补充资源进行生物样本库保存的潜力似乎很大。可用于生物样本库保存的宫颈阴道标本包括巴氏染色单层制片和液基细胞学制片的剩余材料。细针穿刺和非妇科标本的不同类型标本制备，包括巴氏染色和Diff-Quik染色涂片、细胞块，以及细针穿刺的专用穿刺物/剩余材料，保存在各种溶液中冷冻保存，均可用于生物样本库保存。由于在细胞学标本采集、储存和质量评估的操作程序标准方面存在一些知识空白，不仅需要进一步研究以及召开全国性会议和举办研讨会，以提高认识，还需要促进将细胞病理学标本用于生物样本库保存。
