Cullivan Sarah, Boucly Athénaïs, Jevnikar Mitja, Lechartier Benoit, Ulrich Silvia, Bertoletti Laurent, Sitbon Olivier, Vonk-Noordegraaf Anton, Bokan Aleksandar, Park Da-Hee, Genecand Leon, Guiot Julien, Jutant Etienne-Marie, Piccari Lucilla, Lichtblau Mona
The National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland.
National Heart and Lung Institute, Imperial College London, London, UK.
ERJ Open Res. 2024 Feb 26;10(1). doi: 10.1183/23120541.00847-2023. eCollection 2024 Jan.
Pulmonary vascular diseases such as pulmonary embolism and pulmonary hypertension are important and frequently under-recognised conditions. This article provides an overview of key highlights in pulmonary vascular diseases from the European Respiratory Society International Congress 2023. This includes insights into disease modification in pulmonary arterial hypertension and novel therapies such as sotatercept and seralutinib. Exciting developments in our understanding of the mechanisms underpinning pulmonary hypertension associated with interstitial lung disease are also explored. A comprehensive overview of the complex relationship between acute pulmonary embolism and chronic thromboembolic pulmonary hypertension (CTEPH) is provided along with our current understanding of the molecular determinants of CTEPH. The importance of multidisciplinary and holistic care cannot be understated, and this article also addresses advances beyond medication, with a special focus on exercise training and rehabilitation.
肺血管疾病，如肺栓塞和肺动脉高压，是重要且常常未得到充分认识的病症。本文概述了2023年欧洲呼吸学会国际大会上肺血管疾病的关键要点。这包括对肺动脉高压疾病改善的见解以及诸如索他瑞西肽和塞拉鲁替尼等新型疗法。还探讨了我们对与间质性肺疾病相关的肺动脉高压发病机制认识方面的激动人心的进展。本文全面概述了急性肺栓塞与慢性血栓栓塞性肺动脉高压（CTEPH）之间的复杂关系以及我们目前对CTEPH分子决定因素的理解。多学科和整体护理的重要性不容小觑，本文还论述了药物治疗之外的进展，特别关注运动训练和康复。
