2-取代-3-吡啶醇醚类作为降血脂和血小板聚集抑制剂。
2-Substituted-3-pyridinolethers as hypolipidemic and platelet aggregation inhibiting agents.
作者信息
Desideri N, Manna F, Stein M L, Vairo G, Del Gaudio F, Gentile B, Marmo E
出版信息
Farmaco Sci. 1985 Sep;40(9):630-44.
PMID:3841074
Abstract
Some 2-substituted 3-pyridinolethers were synthesized, with one side chain bearing a carboxylic function; among these there are products having structure analogies with the prostaglandins. The results of hypolipidemic and hypocholesterolemic tests on experimental hyperdyslipidemic animals, as well as those on the inhibition of platelets aggregation and on fibrinolytic activity are reported.
摘要
合成了一些2-取代的3-吡啶醇醚，其一侧链带有羧基官能团；其中有一些产物与前列腺素具有结构相似性。报告了对实验性高脂血症动物进行的降血脂和降胆固醇测试结果，以及对血小板聚集抑制和纤溶活性的测试结果。
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