Bendoukha Imene, Boucherit-Otmani Zahia, Baba Ahmed-Kazi Tani Zahira Zakia, Seghir Abdelfettah, Madouni Mourad, Radoui Abdel Karim, Boucherit Kebir
Laboratory Antibiotics Antifungals: Physico-chemical Synthesis and Biological Activity (LapSab), University of Abou Bekr Belkaid, Tlemcen, Algeria.
Faculties of Economics and Business and Management, University of Tahar Moulay, Saida, Algeria.
Pediatr Pulmonol. 2024 May;59(5):1454-1461. doi: 10.1002/ppul.26939. Epub 2024 Feb 27.
Cystic fibrosis (CF) is a rare disease in Algeria, and its prognosis is poor in developing countries. The clinical and demographic knowledge of Algerian pediatric patients diagnosed with CF is incomplete due to the nonexistence of a national medical registry. Hence, the present study is the first Algerian multicentre study on CF.
This retrospective study was conducted in western Algeria. Over 1 year, the study included all pediatric patients with a confirmed diagnosis of CF in the pediatric hospital of Oran. Patient characteristics, clinical manifestations, and the prescribed treatment were reported.
Thirty-four children (16 boys and 18 girls) participated in this study. Only 15 were diagnosed before the age of 6 months. The sweat chloride test was positive in all patients. Respiratory manifestations were found in all patients, chronic diarrhoea in 29 of them, and growth retardation in 10. Moreover, 25 (73.5%) had low to low intermediate socioeconomic levels. After diagnosis, respiratory complications marked the evolution of the 34 patients, with bronchial congestion observed in 33 of them, while 10 (29.4%) patients presented severe bronchopneumonia and 4 (11.8%) were affected by asthma. Consequently, three (8.8%) died at an average age of 9 years mainly because of respiratory failure.
The prognosis of CF is poor in Algeria compared to other developed countries due to the longer diagnostic delay and limited therapeutic alternatives. This representative subset of Algerian pediatric patients with CF will serve as a reference for future studies on CF in Algeria.
囊性纤维化（CF）在阿尔及利亚是一种罕见疾病，在发展中国家其预后较差。由于缺乏全国性的医学登记系统，阿尔及利亚被诊断为CF的儿科患者的临床和人口统计学知识并不完整。因此，本研究是阿尔及利亚第一项关于CF的多中心研究。
这项回顾性研究在阿尔及利亚西部进行。在1年多的时间里，该研究纳入了奥兰儿科医院所有确诊为CF的儿科患者。报告了患者的特征、临床表现和所开的治疗方法。
34名儿童（16名男孩和18名女孩）参与了本研究。只有15名在6个月前被诊断出。所有患者的汗液氯化物试验均呈阳性。所有患者均有呼吸道表现，29名有慢性腹泻，10名有生长发育迟缓。此外，25名（73.5%）的社会经济水平处于低到中低水平。诊断后，呼吸道并发症是这34名患者病情发展的特征，其中33名出现支气管充血，10名（29.4%）患者出现严重支气管肺炎，4名（11.8%）患有哮喘。因此，3名（8.8%）患者平均在9岁时死亡，主要原因是呼吸衰竭。
与其他发达国家相比，阿尔及利亚CF的预后较差，因为诊断延迟时间较长且治疗选择有限。这一具有代表性的阿尔及利亚CF儿科患者子集将为阿尔及利亚未来的CF研究提供参考。
