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[个体化手术治疗胃食管癌]

[Tailored surgery in the treatment of gastroesophageal cancer].

作者信息

Schmidt Thomas, Fuchs Hans F, Thomas Michael N, Müller Dolores T, Lukomski Leandra, Scholz Matthias, Bruns Christiane J

机构信息

Klinik und Poliklinik für Allgemein‑, Viszeral‑, Tumor- und Transplantationschirurgie, Uniklinik Köln, Kerpenerstr. 62, 50937, Köln, Deutschland.

出版信息

Chirurgie (Heidelb). 2024 Apr;95(4):261-267. doi: 10.1007/s00104-024-02056-3. Epub 2024 Feb 27.

DOI:10.1007/s00104-024-02056-3
PMID:38411664
Abstract

The surgical options and particularly perioperative treatment, have significantly advanced in the case of gastroesophageal cancer. This progress enables a 5-year survival rate of nearly 50% to be achieved through curative multimodal treatment concepts for locally advanced cancer. Therefore, in tumor boards and surgical case discussions the question increasingly arises regarding the type of treatment that provides optimal oncological and functional outcomes for individual patients with pre-existing diseases. It is therefore essential to carefully assess whether organ-preserving treatment might also be considered in the future or in what way minimally invasive or robotic surgery can offer advantages. Simultaneously, the boundaries of surgical and oncological treatment are currently being shifted in order to enable curative forms of treatment for patients with pre-existing conditions or those with oligometastatic diseases. With the integration of artificial intelligence into decision-making processes, new possibilities for information processing are increasingly becoming available to incorporate even more data into making decisions in the future.

摘要

对于食管癌,手术选择尤其是围手术期治疗已经取得了显著进展。这一进展使得通过针对局部晚期癌症的多模式治愈性治疗理念,能够实现近50%的5年生存率。因此,在肿瘤多学科讨论组和手术病例讨论中,对于为患有基础疾病的个体患者提供最佳肿瘤学和功能结果的治疗类型的问题日益凸显。因此,仔细评估未来是否也可考虑保留器官的治疗,或者微创或机器人手术能以何种方式带来优势至关重要。同时,目前手术和肿瘤治疗的界限正在发生变化,以便为患有基础疾病或寡转移疾病的患者提供治愈性治疗形式。随着人工智能融入决策过程,未来越来越有可能获得新的信息处理方式,从而在决策中纳入更多数据。

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1
[Tailored surgery in the treatment of gastroesophageal cancer].[个体化手术治疗胃食管癌]
Chirurgie (Heidelb). 2024 Apr;95(4):261-267. doi: 10.1007/s00104-024-02056-3. Epub 2024 Feb 27.
2
[Oncological surgery in the interdisciplinary context-On the way to personalized medicine].[跨学科背景下的肿瘤外科手术——迈向个性化医疗之路]
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[Therapeutic approach in oligometastatic gastric and esophageal cancer].[寡转移胃癌和食管癌的治疗方法]
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Pretherapeutic evaluation of patients with upper gastrointestinal tract cancer using endoscopic and laparoscopic ultrasonography.使用内镜超声和腹腔镜超声对上消化道癌患者进行治疗前评估。
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[Surgical strategy in multimodal treatment of gastric and esophageal cancer].[胃癌和食管癌多模式治疗中的手术策略]
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Chirurg. 2021 Dec;92(12):1094-1099. doi: 10.1007/s00104-021-01475-w. Epub 2021 Aug 13.
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Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer.全球食管和胃食管交界癌治疗中手术技术的趋势
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本文引用的文献

1
Perioperative Atezolizumab Plus Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel for Resectable Esophagogastric Cancer: Interim Results From the Randomized, Multicenter, Phase II/III DANTE/IKF-s633 Trial.可切除食管胃结合部腺癌患者围手术期使用阿替利珠单抗联合氟尿嘧啶、亚叶酸钙、奥沙利铂和多西他赛治疗的随机、多中心、Ⅱ/Ⅲ期 DANTE/IKF-s633 试验的中期结果。
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Laparoscopic ischemic conditioning of the stomach prior to esophagectomy induces gastric neo-angiogenesis.在食管切除术前对胃进行腹腔镜缺血预处理可诱导胃新生血管生成。
Eur J Surg Oncol. 2023 Nov;49(11):107096. doi: 10.1016/j.ejso.2023.107096. Epub 2023 Sep 26.
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Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
三联疗法与围手术期化疗治疗局部晚期食管及食管胃交界腺癌(Neo - AEGIS):一项开放标签、随机、3期试验
Lancet Gastroenterol Hepatol. 2023 Nov;8(11):1015-1027. doi: 10.1016/S2468-1253(23)00243-1. Epub 2023 Sep 18.
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Impact of the Surgical Approach for Neoadjuvantly Treated Gastroesophageal Junction Type II Tumors: A Multinational, High-volume Center Retrospective Cohort Analysis.新辅助治疗胃食管结合部 II 型肿瘤的手术方式的影响:一项多中心、大样本量回顾性队列分析。
Ann Surg. 2023 Nov 1;278(5):683-691. doi: 10.1097/SLA.0000000000006011. Epub 2023 Jul 31.
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Prediction of postoperative complications after oesophagectomy using machine-learning methods.应用机器学习方法预测食管癌手术后并发症。
Br J Surg. 2023 Sep 6;110(10):1361-1366. doi: 10.1093/bjs/znad181.
6
Long-Term Postsurgical Outcomes of Neoadjuvant Chemoradiation (CROSS) Versus Chemotherapy (FLOT) for Multimodal Treatment of Adenocarcinoma of the Esophagus and the Esophagogastric Junction.新辅助放化疗(CROSS方案)与化疗(FLOT方案)用于食管及食管胃交界腺癌多模式治疗的长期术后结局
Ann Surg Oncol. 2023 Nov;30(12):7422-7433. doi: 10.1245/s10434-023-13643-9. Epub 2023 May 21.
7
Artificial intelligence for tumour tissue detection and histological regression grading in oesophageal adenocarcinomas: a retrospective algorithm development and validation study.人工智能用于食管腺癌肿瘤组织检测和组织学消退分级:一项回顾性算法开发与验证研究
Lancet Digit Health. 2023 May;5(5):e265-e275. doi: 10.1016/S2589-7500(23)00027-4.
8
A prospective cohort study on active surveillance after neoadjuvant chemoradiotherapy for esophageal cancer: protocol of Surgery As Needed for Oesophageal cancer-2.新辅助放化疗后食管癌主动监测的前瞻性队列研究:按需手术治疗食管癌-2 研究方案。
BMC Cancer. 2023 Apr 10;23(1):327. doi: 10.1186/s12885-023-10747-z.
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Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe.寡转移食管胃交界部癌的定义、诊断和治疗:欧洲的一项德尔菲共识研究。
Eur J Cancer. 2023 May;185:28-39. doi: 10.1016/j.ejca.2023.02.015. Epub 2023 Feb 24.
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Overall morbidity after total minimally invasive keyhole oesophagectomy versus hybrid oesophagectomy (the MICkey trial): study protocol for a multicentre randomized controlled trial.全微创锁孔与杂交食管切除术(MICkey 试验)后总体发病率:一项多中心随机对照试验的研究方案。
Trials. 2023 Mar 10;24(1):175. doi: 10.1186/s13063-023-07134-1.