反对基因决定论的基因组案例。
The genomic case against genetic determinism.
机构信息
Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana Champaign, Urbana, Illinois, United States of America.
Department of Entomology, University of Illinois Urbana Champaign, Urbana, Illinois, United States of America.
出版信息
PLoS Biol. 2024 Feb 27;22(2):e3002510. doi: 10.1371/journal.pbio.3002510. eCollection 2024 Feb.
Abstract
Animal studies reveal that the molecular wiring of the brain can be altered by heredity, the environment, and their interaction. A deeper molecular understanding of these interactions could be a potent antidote to societal concerns of genetic determinism for human behavior, but this requires a paradigm that extends beyond traditional genome-wide association study (GWAS).
摘要
动物研究表明，大脑的分子结构可以通过遗传、环境及其相互作用来改变。对这些相互作用的更深入的分子理解可能是对抗社会对人类行为的遗传决定论担忧的有力解毒剂，但这需要一种超越传统全基因组关联研究（GWAS）的范式。
相似文献
1
The genomic case against genetic determinism.反对基因决定论的基因组案例。
PLoS Biol. 2024 Feb 27;22(2):e3002510. doi: 10.1371/journal.pbio.3002510. eCollection 2024 Feb.
2
A genome scan conducted in a multigenerational pedigree with convergent strabismus supports a complex genetic determinism.在一个患有共同性斜视的多代家系中进行的全基因组扫描支持复杂的遗传决定论。
PLoS One. 2013 Dec 23;8(12):e83574. doi: 10.1371/journal.pone.0083574. eCollection 2013.
3
Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies.常见和区分物质使用行为和障碍的遗传因素：来自人类和动物研究的基因组和转录组研究的综合分析。
Addiction. 2022 Sep;117(9):2515-2529. doi: 10.1111/add.15908. Epub 2022 May 10.
4
Genomic Study of Infection Level and Its Association With Tick Count in Hereford and Braford Cattle.感染水平的基因组研究及其与赫里福德牛和布拉福德牛蜱计数的关联。
Front Immunol. 2020 Aug 28;11:1905. doi: 10.3389/fimmu.2020.01905. eCollection 2020.
5
Genomic Contextualism, Genetic Determinism, and Causal Models.基因组情境论、基因决定论与因果模型
Am J Bioeth. 2019 Jan;19(1):73-75. doi: 10.1080/15265161.2018.1544317.
6
How Darwinian reductionism refutes genetic determinism.达尔文式还原论如何反驳基因决定论。
Stud Hist Philos Biol Biomed Sci. 2006 Mar;37(1):122-35. doi: 10.1016/j.shpsc.2005.12.005. Epub 2006 Jan 24.
7
Phenotype-Genotype Integrator (PheGenI): synthesizing genome-wide association study (GWAS) data with existing genomic resources.表型-基因型整合器（PheGenI）：将全基因组关联研究（GWAS）数据与现有基因组资源进行整合。
Eur J Hum Genet. 2014 Jan;22(1):144-7. doi: 10.1038/ejhg.2013.96. Epub 2013 May 22.
8
Genetic determinants of voluntary exercise.自愿运动的遗传决定因素。
Trends Genet. 2013 Jun;29(6):348-57. doi: 10.1016/j.tig.2012.12.007. Epub 2013 Jan 23.
9
Status and prospects of genome-wide association studies in plants.植物全基因组关联研究的现状与展望。
Plant Genome. 2021 Mar;14(1):e20077. doi: 10.1002/tpg2.20077. Epub 2021 Jan 13.
10
GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS.GW-SEM 2.0：高效、灵活且易于访问的多元 GWAS。
Behav Genet. 2021 May;51(3):343-357. doi: 10.1007/s10519-021-10043-1. Epub 2021 Feb 19.
本文引用的文献
1
Social network position is a major predictor of ant behavior, microbiota composition, and brain gene expression.社会网络地位是蚂蚁行为、微生物群落组成和大脑基因表达的主要预测因子。
PLoS Biol. 2023 Jul 24;21(7):e3002203. doi: 10.1371/journal.pbio.3002203. eCollection 2023 Jul.
2
Single-cell dissection of aggression in honeybee colonies.蜜蜂群体中攻击行为的单细胞剖析
Nat Ecol Evol. 2023 Aug;7(8):1232-1244. doi: 10.1038/s41559-023-02090-0. Epub 2023 Jun 1.
3
Panel urges caution in tying social, behavioral traits to genes.专家组敦促在将社会和行为特征与基因联系起来时要谨慎。
Science. 2023 Apr 28;380(6643):327-328. doi: 10.1126/science.adi4368. Epub 2023 Apr 27.
4
Comparative genomics and the roots of human behavior.比较基因组学与人类行为的根源。
Trends Cogn Sci. 2023 Mar;27(3):230-232. doi: 10.1016/j.tics.2022.12.012. Epub 2023 Jan 7.
5
The missing link between genetic association and regulatory function.遗传关联与调控功能之间缺失的环节。
Elife. 2022 Dec 14;11:e74970. doi: 10.7554/eLife.74970.
6
The emergence and development of behavioral individuality in clonal fish.克隆鱼类行为个体性的出现和发展。
Nat Commun. 2022 Oct 28;13(1):6419. doi: 10.1038/s41467-022-34113-y.
7
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.在 300 万人的全基因组关联分析中，对家庭内和家庭间的受教育程度进行多基因预测。
Nat Genet. 2022 Apr;54(4):437-449. doi: 10.1038/s41588-022-01016-z. Epub 2022 Mar 31.
8
Gene-lifestyle interactions in the genomics of human complex traits.基因-生活方式相互作用在人类复杂特征的基因组学中。
Eur J Hum Genet. 2022 Jun;30(6):730-739. doi: 10.1038/s41431-022-01045-6. Epub 2022 Mar 22.
9
An Expanded View of Complex Traits: From Polygenic to Omnigenic.复杂性状的扩展观点：从多基因到泛基因
Cell. 2017 Jun 15;169(7):1177-1186. doi: 10.1016/j.cell.2017.05.038.
10
Genomic Analysis of Genotype-by-Social Environment Interaction for Aggressive Behavior.攻击行为的基因型与社会环境相互作用的基因组分析
Genetics. 2017 Aug;206(4):1969-1984. doi: 10.1534/genetics.117.200642. Epub 2017 May 26.
Zotero 插件