Gillespie W R, Veng-Pedersen P
J Pharmacokinet Biopharm. 1985 Jun;13(3):289-307. doi: 10.1007/BF01065657.
A new deconvolution algorithm (DCON) suitable for pharmacokinetic applications is presented. It requires that both the impulse and input responses, typically systemic drug levels, be well described by polyexponential equations. DCON has a wider range of applications than an earlier method (DECONV) from which it is derived. A FORTRAN program is provided, making implementation of the technique a simple matter. DCON is demonstrated to evaluate the "GI bioavailability," defined as the rate and the extent of gastrointestinal drug release, of various ibuprofen dosage forms. The GI drug release kinetics exemplifies a pharmacokinetic system which cannot be evaluated using the previous deconvolution algorithm (DECONV) because of an initial zero drug level response. This limitation is not found in DCON. It is also demonstrated how the mean in vivo dissolution time MDT can be evaluated by deconvolution.
本文介绍了一种适用于药代动力学应用的新型反卷积算法（DCON）。它要求脉冲响应和输入响应（通常为全身药物水平）都能用多指数方程很好地描述。与它所衍生的早期方法（DECONV）相比，DCON具有更广泛的应用范围。文中提供了一个FORTRAN程序，使得该技术的实现变得简单。DCON被证明可用于评估各种布洛芬剂型的“胃肠道生物利用度”，其定义为胃肠道药物释放的速率和程度。胃肠道药物释放动力学示例了一种药代动力学系统，由于初始药物水平响应为零，无法使用先前的反卷积算法（DECONV）进行评估。而DCON不存在这一局限性。文中还展示了如何通过反卷积来评估平均体内溶出时间（MDT）。
