Boros P, Bodolay E, Szabó G, Balázs G, Szegedi G
Neoplasma. 1985;32(6):709-14.
Fourteen patients suffering from highly differentiated thyroid cancer and 10 patients with autoimmune thyroid disease were tested in the present study. The tumor-specific autologous rosette formation of peripheral monocytes was determined and was found to be increased in cancer patients. Using the monocytes as effector and the covered, prelabelled autologous red blood cells as target, a cytotoxic assay was carried out. The rosette formation and cytotoxic ability correlated with the time passed since the operation, present clinical stage and the expansion of tumor found during the operation. In Hashimoto thyreoditis and Graves' disease elevated rosette formation and normal cytotoxic ability were detected.
本研究对14例高分化甲状腺癌患者和10例自身免疫性甲状腺疾病患者进行了检测。测定了外周血单核细胞的肿瘤特异性自体花环形成，发现癌症患者的该指标有所增加。以单核细胞作为效应细胞，以包被的、预先标记的自体红细胞作为靶细胞，进行了细胞毒性试验。花环形成和细胞毒性能力与手术时间、当前临床分期以及手术中发现的肿瘤扩展情况相关。在桥本甲状腺炎和格雷夫斯病中，检测到花环形成增加而细胞毒性能力正常。
