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老年人糖尿病患者跌倒的风险因素：系统评价和荟萃分析。

Risk factors for falls in older adults with diabetes mellitus: systematic review and meta-analysis.

机构信息

Postgraduate course in Health Sciences and Technologies, University of Brasília (UnB) - Campus Ceilândia, Brasília, DF, Brazil.

Faculty of Medicine, Centro Universitário Euro-Americano (Unieuro), Brasília, Brazil.

出版信息

BMC Geriatr. 2024 Feb 28;24(1):201. doi: 10.1186/s12877-024-04668-0.

DOI:10.1186/s12877-024-04668-0
PMID:38413865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10900672/
Abstract

AIM

To identify risk factors for falls in older adults with Type 2 Diabetes Mellitus (T2DM).

METHODS

The eligible studies identified factors associated with the risk of falls in older adults with T2DM. We searched PubMed, Cinahl, Web of Science, Scopus, and the Cochrane Library databases. The review has been updated and the last review date was November 30, 2023 (CRD42020193461).

RESULTS

Twelve studies met the inclusion criteria, and eight studies were included in the meta-analysis. These studies included a total of 40,778 older adults with T2DM, aged 60 to 101 years. The risk of developing the outcome falls in older adults with T2DM is 63% higher compared to the risk in older adults without T2DM (HR 1.63; 95% CI [1.30 - 2.05]). The overall chance of falling in older adults with T2DM is 59% higher than that of non-diabetic older adults (OR 1.59; 95% CI [1.36 -1.87]), and in older adults with T2DM who take insulin the chance of falling is 162% higher (OR 2.62; 95% CI [1.87 - 3.65]). No results on diabetic polyneuropathy were found in the studies.

CONCLUSION

Older adults with T2DM present a higher risk of falls compared to non-diabetics. Among the included older adults with T2DM, the most important factor associated with a higher risk of falls was insulin use.

TRIAL REGISTRATION

Registered in the International Prospective Register of Systematic Reviews (CRD42020193461).

摘要

目的

确定 2 型糖尿病（T2DM）老年患者发生跌倒的风险因素。

方法

合格研究确定了与 T2DM 老年患者跌倒风险相关的因素。我们检索了 PubMed、Cinahl、Web of Science、Scopus 和 Cochrane Library 数据库。本次综述已更新，最后检索日期为 2023 年 11 月 30 日（CRD42020193461）。

结果

共有 12 项研究符合纳入标准，其中 8 项研究纳入荟萃分析。这些研究共纳入 40778 例年龄在 60 至 101 岁的 T2DM 老年患者。与非 T2DM 老年患者相比，T2DM 老年患者发生跌倒结局的风险高 63%（HR 1.63；95%CI [1.30-2.05]）。T2DM 老年患者跌倒的总体风险比非糖尿病老年患者高 59%（OR 1.59；95%CI [1.36-1.87]），使用胰岛素的 T2DM 老年患者跌倒的风险高 162%（OR 2.62；95%CI [1.87-3.65]）。研究中未发现糖尿病性多神经病的相关结果。

结论

与非糖尿病患者相比，T2DM 老年患者跌倒的风险更高。在纳入的 T2DM 老年患者中，与跌倒风险增加相关的最重要因素是使用胰岛素。

试验注册

国际前瞻性系统评价注册库（CRD42020193461）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/f11f1fd36f1c/12877_2024_4668_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/9b8509483267/12877_2024_4668_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/67881d43e04e/12877_2024_4668_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/e655153d3289/12877_2024_4668_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/f11f1fd36f1c/12877_2024_4668_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/9b8509483267/12877_2024_4668_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/67881d43e04e/12877_2024_4668_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/e655153d3289/12877_2024_4668_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8817/10900672/f11f1fd36f1c/12877_2024_4668_Fig4_HTML.jpg

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