School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China.
Front Immunol. 2024 Feb 13;15:1338178. doi: 10.3389/fimmu.2024.1338178. eCollection 2024.
Hematopoietic stem cells (HSCs) undergo self-renewal and differentiation in the bone marrow, which is tightly regulated by cues from the microenvironment. The gut microbiota, a dynamic community residing on the mucosal surface of vertebrates, plays a crucial role in maintaining host health. Recent evidence suggests that the gut microbiota influences HSCs differentiation by modulating the bone marrow microenvironment through microbial products. This paper comprehensively analyzes the impact of the gut microbiota on hematopoiesis and its effect on HSCs fate and differentiation by modifying the bone marrow microenvironment, including mechanical properties, inflammatory signals, bone marrow stromal cells, and metabolites. Furthermore, we discuss the involvement of the gut microbiota in the development of hematologic malignancies, such as leukemia, multiple myeloma, and lymphoma.
造血干细胞（HSCs）在骨髓中进行自我更新和分化，这一过程受到来自微环境的信号的严格调控。肠道微生物群是栖息在脊椎动物黏膜表面的一个动态群落，在维持宿主健康方面发挥着关键作用。最近的证据表明，肠道微生物群通过调节骨髓微环境来影响 HSCs 的分化，这种调节是通过微生物产物实现的。本文通过改变骨髓微环境，包括力学特性、炎症信号、骨髓基质细胞和代谢物，全面分析了肠道微生物群对造血的影响及其对 HSCs 命运和分化的影响。此外，我们还讨论了肠道微生物群在血液系统恶性肿瘤（如白血病、多发性骨髓瘤和淋巴瘤）发展中的作用。
