日本产具有降低碳青霉烯类药物敏感性的相关种属的临床分离株，其青霉素结合蛋白的氨基酸取代。
Clinical isolates of -related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan.
机构信息
Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
出版信息
Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0117923. doi: 10.1128/aac.01179-23. Epub 2024 Feb 28.
Abstract
group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as using partial sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among group isolates in Japan.
摘要
已报道具有较低碳青霉烯类药物敏感性的 组分离株，但在日本其分离率尚不清楚。我们收集了 356 株临床甲型溶血性链球菌分离株，并通过部分测序鉴定出其中 142 株为 。美罗培南不敏感率为 17.6%（25/142）。所有 25 株碳青霉烯类药物不敏感的分离株均在 PBP1A、PBP2B 和 PBP2X 的保守基序中或附近携带氨基酸取代。日本 组分离株中碳青霉烯类药物不敏感较为常见。
相似文献
1
Clinical isolates of -related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan.日本产具有降低碳青霉烯类药物敏感性的相关种属的临床分离株，其青霉素结合蛋白的氨基酸取代。
Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0117923. doi: 10.1128/aac.01179-23. Epub 2024 Feb 28.
2
Insight into the Diversity of Penicillin-Binding Protein 2x Alleles and Mutations in Viridans Streptococci.深入了解草绿色链球菌中青霉素结合蛋白2x等位基因和突变的多样性
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02646-16. Print 2017 May.
3
Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan.日本耐美罗培南肺炎链球菌 19A-CC3111 血清型青霉素结合蛋白分型、抗生素耐药基因鉴定及分子系统发育分析。
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.00711-19. Print 2019 Sep.
4
serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from .经常定植于人类鼻咽部的血清型是青霉素结合蛋白基因片段的常见接受体来自.
Microb Genom. 2021 Sep;7(9). doi: 10.1099/mgen.0.000622.
5
Relatedness among penicillin-binding protein 2b genes of Streptococcus mitis, Streptococcus oralis, and Streptococcus pneumoniae.缓症链球菌、口腔链球菌和肺炎链球菌青霉素结合蛋白2b基因之间的相关性。
Microb Drug Resist. 1995 Spring;1(1):35-42. doi: 10.1089/mdr.1995.1.35.
6
Metabolic changes associated with adaptive resistance to daptomycin in Streptococcus mitis-oralis.与屎肠球菌-口腔链球菌对达托霉素适应性耐药相关的代谢变化。
BMC Microbiol. 2020 Jun 15;20(1):162. doi: 10.1186/s12866-020-01849-w.
7
Antibiotic modulation of the plasminogen binding ability of viridans group streptococci.肺炎链球菌对纤溶酶原结合能力的抗生素调节作用。
Antimicrob Agents Chemother. 2012 Jan;56(1):458-63. doi: 10.1128/AAC.00452-11. Epub 2011 Oct 28.
8
Low penicillin susceptibility in from bloodstream infections in pediatric populations.血流感染患儿分离的 青霉素低敏率。
Microbiol Spectr. 2024 Nov 5;12(11):e0135024. doi: 10.1128/spectrum.01350-24. Epub 2024 Oct 14.
9
Crossing the barrier: evolution and spread of a major class of mosaic pbp2x in Streptococcus pneumoniae, S. mitis and S. oralis.跨越屏障：肺炎链球菌、缓症链球菌和口腔链球菌中一类主要嵌合pbp2x的进化与传播
Int J Med Microbiol. 2007 Nov;297(7-8):503-12. doi: 10.1016/j.ijmm.2007.02.009. Epub 2007 Apr 24.
10
Isolation of Group A Streptococci with Reduced β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan.日本分离出具有青霉素结合蛋白氨基酸取代的β-内酰胺类药物低敏性 A 组链球菌。
Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0148221. doi: 10.1128/AAC.01482-21. Epub 2021 Oct 4.
引用本文的文献
1
Prevalence and antimicrobial resistance of isolated from local pig breeds in Jiangxi Province, China.中国江西省本地猪种中分离出的[具体内容未给出，可能是某种病原体等]的流行情况及抗菌药物耐药性
Front Vet Sci. 2025 Aug 4;12:1582461. doi: 10.3389/fvets.2025.1582461. eCollection 2025.
2
Molecular characterization of a novel putative pathogen, sp. nov., isolated from sputum culture.从痰培养物中分离到的新型潜在病原体 sp. nov. 的分子特征。
Microbiol Spectr. 2024 Oct 3;12(10):e0135424. doi: 10.1128/spectrum.01354-24. Epub 2024 Sep 13.
本文引用的文献
1
Prosthetic valve endocarditis due to highly beta-lactam-resistant : a case report.耐β-内酰胺类抗生素所致人工瓣膜心内膜炎：一例报告
Access Microbiol. 2022 Nov 3;4(11):acmi000437. doi: 10.1099/acmi.0.000437. eCollection 2022.
2
Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020.2010年至2020年美国草绿色链球菌分离株的抗生素敏感性模式
JAC Antimicrob Resist. 2022 May 19;4(3):dlac049. doi: 10.1093/jacamr/dlac049. eCollection 2022 Jun.
3
Identification and characterisation of a novel multidrug-resistant streptococcus, Streptococcus toyakuensis sp. nov., from a blood sample.从血样中鉴定和表征一种新型耐多药链球菌，即 toyakuensis 链球菌。
J Glob Antimicrob Resist. 2022 Jun;29:316-322. doi: 10.1016/j.jgar.2022.04.018. Epub 2022 Apr 29.
4
Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan.日本耐美罗培南肺炎链球菌 19A-CC3111 血清型青霉素结合蛋白分型、抗生素耐药基因鉴定及分子系统发育分析。
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.00711-19. Print 2019 Sep.
5
Endocarditis Caused by Highly Penicillin-Resistant Viridans Group Streptococci: Still Room for Vancomycin-Based Regimens.由高度耐青霉素的草绿色链球菌引起的心内膜炎：万古霉素为基础的治疗方案仍有一席之地。
Antimicrob Agents Chemother. 2019 Jul 25;63(8). doi: 10.1128/AAC.00516-19. Print 2019 Aug.
6
Third-generation cephalosporin and carbapenem resistance in Streptococcus mitis/oralis. Results from a nationwide registry in the Netherlands.轻/口腔链球菌对第三代头孢菌素和碳青霉烯类抗生素的耐药性。荷兰全国登记处的结果。
Clin Microbiol Infect. 2019 Apr;25(4):518-520. doi: 10.1016/j.cmi.2018.11.021. Epub 2018 Dec 4.
7
Insight into the Diversity of Penicillin-Binding Protein 2x Alleles and Mutations in Viridans Streptococci.深入了解草绿色链球菌中青霉素结合蛋白2x等位基因和突变的多样性
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02646-16. Print 2017 May.
8
Development and validation of a clinical model to predict the presence of β-lactam resistance in viridans group streptococci causing bacteremia in neutropenic cancer patients.建立并验证一个临床模型，以预测引起中性粒细胞减少癌症患者菌血症的草绿色链球菌属中β-内酰胺类耐药的存在。
Clin Infect Dis. 2014 Jul 15;59(2):223-30. doi: 10.1093/cid/ciu260. Epub 2014 Apr 21.
9
Infective endocarditis due to penicillin-resistant viridans group streptococci.由耐青霉素的草绿色链球菌引起的感染性心内膜炎。
Clin Infect Dis. 2007 Jun 15;44(12):1585-92. doi: 10.1086/518174. Epub 2007 May 8.
10
Crossing the barrier: evolution and spread of a major class of mosaic pbp2x in Streptococcus pneumoniae, S. mitis and S. oralis.跨越屏障：肺炎链球菌、缓症链球菌和口腔链球菌中一类主要嵌合pbp2x的进化与传播
Int J Med Microbiol. 2007 Nov;297(7-8):503-12. doi: 10.1016/j.ijmm.2007.02.009. Epub 2007 Apr 24.
Zotero 插件