Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Department of Plastic and Craniofacial Surgery, Karolinska University Hospital, Stockholm, Sweden.
BJS Open. 2024 Jan 3;8(1). doi: 10.1093/bjsopen/zrae003.
The Swedish Breast Reconstruction Outcome Study (SweBRO) initiative is a nationwide study with the primary aim of assessing long-term outcomes after mastectomy with and without breast reconstruction (BR). The current part (SweBRO 2) is designed to evaluate health-related quality of life (HRQoL), with the hypothesis that BR has a positive impact on patient-reported HRQoL in the long-term.
Women who underwent mastectomy in Sweden in 2000, 2005, or 2010 and were alive at the time of the survey were identified through the National Breast Cancer Registry. Eligible participants received formal invitation letters to take part in a survey evaluating their HRQoL at 5 , 10, or 15 years post-mastectomy. The EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-3L questionnaires were employed.
Of 2904 respondents (50% of 5853 invited), 895 (31%) had received BR. Among them, 516 (58%) were reconstructed with implants and 281 (31%) with autologous tissue. Women with BR scored significantly better in the EORCT QLQ-C30 physical functioning domain (mean 90 versus 81 points), fatigue (mean 21 versus 25), and dyspnoea (mean 16 versus 22) compared to non-reconstructed women. The EORTC QLQ-BR23 revealed that women with BR experienced favourable sexual functioning compared with non-reconstructed women (mean 26 versus 14). The EQ-5D-3L visual analogue scale score was similar between groups.
The current study underscores the benefits of BR for long-term well-being, for example, in terms of physical and sexual functioning. These underline the importance of informing women undergoing mastectomy about BR alternatives and its potential benefits in enhancing long-term well-being.
瑞典乳房重建结局研究（SweBRO）倡议是一项全国性研究，主要目的是评估乳房切除术伴或不伴乳房重建（BR）后的长期结局。当前部分（SweBRO 2）旨在评估与健康相关的生活质量（HRQoL），假设 BR 对长期患者报告的 HRQoL 有积极影响。
通过国家乳腺癌登记处确定 2000 年、2005 年或 2010 年在瑞典接受乳房切除术且在调查时仍存活的女性。合格的参与者收到正式邀请信，参加一项评估他们乳房切除术 5 年、10 年或 15 年后 HRQoL 的调查。使用 EORTC QLQ-C30、EORTC QLQ-BR23 和 EQ-5D-3L 问卷。
在 2904 名应答者（5853 名受邀者的 50%）中，895 名（31%）接受了 BR。其中，516 名（58%）用植入物重建，281 名（31%）用自体组织重建。BR 的女性在 EORCT QLQ-C30 身体功能领域（平均 90 分对 81 分）、疲劳（平均 21 分对 25 分）和呼吸困难（平均 16 分对 22 分）方面的得分明显更高。EORTC QLQ-BR23 显示，BR 的女性的性功能比未重建的女性更有利（平均 26 分对 14 分）。EQ-5D-3L 视觉模拟量表评分在两组之间相似。
当前的研究强调了 BR 对长期幸福感的益处，例如在身体和性功能方面。这些强调了告知接受乳房切除术的女性 BR 替代方案及其在增强长期幸福感方面的潜在益处的重要性。
