Nilius B
Pharmazie. 1985 Dec;40(12):855-6.
Electrical effects of the new antiarrhythmic compound Bonnecor (AWD 19-166, GS 015) were studied under conditions known to increase the intracellular Ca2+ activity (extracellular K+-deprivation, application of glycosides). In K+ free solutions right ventricular papillary muscles showed an extreme acceleration of the initial repolarization indicating an intracellular Ca overload. AWD 19-166 could not prevent the initial shortening of action potentials and seems to be less effective in K+ free than in K+ containing solutions. In partially depolarized (22 mmol/lK+) right ventricular papillary muscles oscillatory afterdepolarizations were not suppressed by AWD 19-166. However, the compound prevented the generation of irregular action potentials triggered by the afterdepolarizations.
在已知会增加细胞内钙离子活性的条件下（细胞外钾离子缺失、应用糖苷），对新型抗心律失常化合物博内可（AWD 19 - 166，GS 015）的电效应进行了研究。在无钾溶液中，右心室乳头肌显示出初始复极化的极度加速，表明细胞内钙超载。AWD 19 - 166无法阻止动作电位的初始缩短，并且在无钾溶液中似乎比在含钾溶液中效果更差。在部分去极化（22 mmol/l钾离子）的右心室乳头肌中，振荡性后去极化未被AWD 19 - 166抑制。然而，该化合物阻止了由后去极化触发的不规则动作电位的产生。
