抗心律失常化合物Bonnecor（AWD 19 - 166，GS 015）的变力作用
Inotropic effects of the antiarrhythmic compound Bonnecor (AWD 19-166, GS 015).
作者信息
Nilius B, Schumann M
出版信息
Pharmazie. 1985 Dec;40(12):854.
PMID:3841601
Abstract
The inotropic effects of the new antiarrhythmic compound AWD 19-166 have been studied at constantly driven isolated left atria of guinea pig (weight between 250 and 350 g). AWD 19-166 exerted dose-dependently negative inotropic effects. Half maximum effects were measured at 1.7 mg/l (n = 7). At concentrations higher than 5 mg/l the negative inotropic effects were found to be irreversible.
摘要
新型抗心律失常化合物AWD 19 - 166对豚鼠（体重250至350克）持续驱动的离体左心房的变力作用进行了研究。AWD 19 - 166呈现出剂量依赖性负性变力作用。半数最大效应在1.7毫克/升时测得（n = 7）。在浓度高于5毫克/升时，发现负性变力作用是不可逆的。
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