Nilius B, Benndorf K, Schüttler K, Boldt W
Pharmazie. 1985 Dec;40(12):852-4.
A new antiarrhythmic compound (Bonnecor AWD 19-166, GS 015) was studied in its effects on the fast sodium channel in two types of cardiac preparations (rabbit ventricular myocardium, frog atrial trabecules). AWD 19-166 depressed the maximum upstroke velocity of the action potentials in ventricular myocardium (50% inhibition at 5 X 10(-6) mol/l) and decreased the fast inward current in frog atrial myocardium. High frequent trains of pacing pulses produced a pacing dependent extra block of both the maximal upstroke velocity and the fast inward current. It is concluded that AWD 19-166 blocks the fast sodium channel in a use dependent manner.
一种新型抗心律失常化合物（Bonnecor AWD 19 - 166，GS 015）在两种心脏标本（兔心室肌、蛙心房小梁）中对快速钠通道的作用进行了研究。AWD 19 - 166降低了心室肌动作电位的最大上升速度（在5×10⁻⁶mol/L时抑制50%），并减少了蛙心房肌中的快速内向电流。高频起搏脉冲串产生了与起搏相关的最大上升速度和快速内向电流的额外阻滞。得出结论：AWD 19 - 166以使用依赖的方式阻断快速钠通道。
