Kaverina N V, Rodionov A P, Berdjajev S J, Darinskij N W, Sulakvelidze M T, Klemm W
Pharmazie. 1985 Dec;40(12):868-9.
The antiarrhythmic action of GS 015 was studied proportionally to its plasma concentrations ascertained in parallel, using the model of the electrofibrillation of the cat's heart. Blood levels of about 1.3 micrograms/ml after i.v. injection of 2 mg/kg caused a marked short-term increase of the fibrillation threshold which then remained at the increased level for a longer period yet, observing GS 015 concentrations between 0.8 and 0.5 micrograms/ml. Individual differences existed in the height of the blood level as well as in its proportion to the effect.
采用猫心颤动模型，按照与同时测定的血浆浓度成比例的方式，研究了GS 015的抗心律失常作用。静脉注射2mg/kg后，血药浓度约为1.3μg/ml时，可使颤动阈值显著短期升高，随后在较长时间内维持在升高水平，此时GS 015浓度在0.8至0.5μg/ml之间。血药浓度的高低及其与效应的比例存在个体差异。
