Rostock A, Hoffmann W, Ploen U, Bartsch R
Pharmazie. 1985 Dec;40(12):875-8.
The substance GS 015 was tested as to its influence on the vegetative and the central nervous system. The total of side effects is low. In spite of the structural resemblance the aspect of action does not correspond to that of tricyclic psychopharmaceutical agents. Pharmacologically relevant doses bring about: local anaesthesia, musculotropic spasmolysis, inhibition of the serotonin-induced oedema, antiulcerative effect, intensification of the toxicity of amphetamine. The results do not oppose to a clinical use.
对GS 015这种物质就其对植物神经系统和中枢神经系统的影响进行了测试。副作用总数较低。尽管在结构上有相似之处,但其作用方式与三环类精神药物不同。药理学相关剂量会产生:局部麻醉、肌促性解痉作用、抑制血清素诱导的水肿、抗溃疡作用、增强苯丙胺的毒性。这些结果并不反对其临床应用。