在大肠杆菌核糖体突变体中受影响的核糖体亚基组装，该突变体具有改变的L22蛋白。

Assembly of ribosomal subunits affected in a ribosomal mutant of E. coli having an altered L22 protein.

作者信息

Pardo D, Vola C, Rosset R

出版信息

Mol Gen Genet. 1979 Jul 2;174(1):53-8. doi: 10.1007/BF00433305.

DOI:10.1007/BF00433305

Abstract

In this article we describe some in vivo properties of a coldsensitive ribosomal mutant from Escherichia coli. The mutation affects the rplV gene which is the structural gene of ribosomal protein L22. Our work shows that at 22 degrees C, the biosynthesis of both ribosomal subunits and the maturation processing of 15S and 23S ribosomal RNA are impaired. Integration of our results in a general model of in vivo ribosomal assembly in E. coli is presented.

摘要

在本文中，我们描述了来自大肠杆菌的一个温度敏感型核糖体突变体的一些体内特性。该突变影响rplV基因，它是核糖体蛋白L22的结构基因。我们的研究表明，在22摄氏度时，两个核糖体亚基的生物合成以及15S和23S核糖体RNA的成熟加工均受到损害。我们将研究结果整合到大肠杆菌体内核糖体组装的通用模型中。

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