细菌核糖体的结构与功能。XI. 50S核糖体组装对30S亚基同步组装的依赖性。
Structure and function of bacterial ribosomes. XI. Dependence of 50S ribosomal assembly on simultaneous assembly of 30S subunits.
作者信息
Nashimoto H, Nomura M
出版信息
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1440-7. doi: 10.1073/pnas.67.3.1440.
Abstract
Some spectinomycin-resistant mutants of Escherichia coli are cold-sensitive. They are unable to assemble both 30S and 50S ribosomal subunits at low temperatures. They accumulate two kinds of incomplete particles, related to 30S and 50S subunits respectively. A single mutation, causing an alteration in a 30S ribosomal component, is responsible for these phenotypes. These results show that assembly of 50S subunits in vivo is dependent on simultaneous assembly of 30S subunits. On the other hand, the assembly of 30S subunits appears to be independent of 50S assembly.
摘要
一些对壮观霉素耐药的大肠杆菌突变体对温度敏感。它们在低温下无法组装30S和50S核糖体亚基。它们积累了两种分别与30S和50S亚基相关的不完整颗粒。一个导致30S核糖体组分发生改变的单一突变导致了这些表型。这些结果表明，50S亚基在体内的组装依赖于30S亚基的同时组装。另一方面，30S亚基的组装似乎不依赖于50S亚基的组装。
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