Prod'hom G, Hedinger C
Ann Pathol. 1985;5(4-5):265-70.
Considering the fact that there is often a combined occurrence of focal lymphocytic thyroiditis (FLT) and so-called Solid Cell Nests (SCN) in the same human thyroid gland, we examined thyroid tissue of 500 routine autopsies. SCN were found in 56 (11.2%) and FLT in 59 (11.8%) patients. The combination of these two lesions was encountered in 18 (3.6%) cases. This incidence (3.6%) is four to five times higher than would be expected from chance alone. In 12 of the 18 patients mentioned, SCN were in close association with lymphocytic infiltration, but this was not statistically significant. Two hypotheses are discussed concerning the combination of SCN and FLT. According to Klinck and Menk (1951), the SCN, derived like the epithelial part of the thymus from the embryologic pharyngeal pouch, forms a favorable micro-environment for inflammatory cells. Based on the second hypothesis, the SCN, probably a remnant of the ultimobranchial body, mark an incompletely developed thyroid. These thyroids would be predisposed to auto-immune thyroid disease such as FLT.
鉴于在同一人体甲状腺中常同时出现局灶性淋巴细胞性甲状腺炎（FLT）和所谓的实性细胞巢（SCN），我们检查了500例常规尸检的甲状腺组织。在56例（11.2%）患者中发现了SCN，在59例（11.8%）患者中发现了FLT。这两种病变同时出现的情况在18例（3.6%）中被发现。这一发生率（3.6%）比仅由偶然因素预期的高出四到五倍。在上述18例患者中的12例中，SCN与淋巴细胞浸润密切相关，但这在统计学上并不显著。讨论了关于SCN和FLT合并出现的两种假说。根据克林克和门克（1951年）的观点，SCN如同胸腺的上皮部分一样起源于胚胎咽囊，为炎症细胞形成了一个有利的微环境。基于第二种假说，SCN可能是最后鳃体的残余，标志着甲状腺发育不完全。这些甲状腺易于发生自身免疫性甲状腺疾病，如FLT。
