Sato K, Miyakawa M, Han D C, Kato S, Shibagaki Y, Tsushima T, Shizume K
J Endocrinol Invest. 1985 Dec;8(6):551-5. doi: 10.1007/BF03348560.
A 38-year-old man with Graves' disease taking propylthiouracil (PTU) for 6 years developed neutropenia and marked splenomegaly. After subtotal thyroidectomy with discontinuance of PTU the patient remained asymptomatic for the last two and half years. The serum obtained during the period of neutropenia demonstrated opsonic activity to neutrophils of the patient as well as of normal volunteers. This opsonic antineutrophil activity was located in the IgG fraction of the serum. Furthermore, PTU at the concentration (0.1-1.0 micrograms/ml) attainable in the patient's serum significantly stimulated [3H] thymidine incorporation in the patient's lymphocytes. These findings indicate that the patient developed autoimmune neutropenia by producing opsonic antineutrophil antibodies in association with the PTU therapy.
一名38岁患有格雷夫斯病的男性服用丙硫氧嘧啶（PTU）6年后出现中性粒细胞减少和明显脾肿大。在接受甲状腺次全切除并停用PTU后，患者在过去两年半一直无症状。中性粒细胞减少期间获得的血清对该患者以及正常志愿者的中性粒细胞表现出调理活性。这种调理抗中性粒细胞活性位于血清的IgG部分。此外，患者血清中可达到的浓度（0.1 - 1.0微克/毫升）的PTU显著刺激了患者淋巴细胞中[3H]胸苷的掺入。这些发现表明，该患者在PTU治疗过程中通过产生调理抗中性粒细胞抗体而发生了自身免疫性中性粒细胞减少。
