Takaya Kazuhiko, Kimura Natsumi, Hiyoshi Toru
Division of Diabetes and Endocrinology, Japanese Red Cross Medical Center, Japan.
Intern Med. 2016;55(24):3627-3633. doi: 10.2169/internalmedicine.55.7379. Epub 2016 Dec 15.
We herein report the case of a 38-year-old Japanese woman with antithyroid arthritis syndrome who experienced severe migratory polyarthritis after the initiation of thiamazole therapy. The patient's symptoms promptly disappeared without any sequelae after the withdrawal of the drug. Antithyroid arthritis syndrome is poorly characterized, and the findings from our literature review indicate that this syndrome exhibits serological features that are distinct from those of antithyroid agent-induced vasculitis syndrome. The absence of autoantibodies, especially anti-neutrophil cytoplasmic antibodies, may help characterize and diagnose antithyroid arthritis syndrome. Furthermore, physicians' awareness of this syndrome is essential for its diagnosis in clinical practice.
我们在此报告一例38岁的日本女性抗甲状腺关节炎综合征患者，她在开始服用甲巯咪唑治疗后出现了严重的游走性多关节炎。停药后，患者症状迅速消失，无任何后遗症。抗甲状腺关节炎综合征的特征尚不明确，我们的文献综述结果表明，该综合征具有与抗甲状腺药物诱导的血管炎综合征不同的血清学特征。自身抗体的缺乏，尤其是抗中性粒细胞胞浆抗体的缺乏，可能有助于抗甲状腺关节炎综合征的特征描述和诊断。此外，医生对该综合征的认识对于其在临床实践中的诊断至关重要。
