Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan; Faculty of Health and Medical Sciences, Kanagawa Institute of Technology, Kanagawa 243-0292, Japan.
Fitoterapia. 2024 Apr;174:105877. doi: 10.1016/j.fitote.2024.105877. Epub 2024 Feb 28.
Phytochemical study on the roots of a medicinal plant Ferula communis L. (Apiaceae) resulted in the isolation of 20 sesquiterpenes including 12 previously undescribed compounds, dauferulins A-L (1-12). The detailed spectroscopic analysis revealed 1-12 to be daucane-type sesquiterpenes with a p-methoxybenzoyloxy group at C-6. The absolute configurations of 1-12 were deduced by analysis of the ECD spectra. Dauferulins A-L (1-12), known sesquiterpenes (13-20), and analogues (14a-14l) derived from 6-O-p-methoxybenzoyl-10α-angeloyloxy-jeaschkeanadiol (14) were evaluated for their effects on AMPK phosphorylation in human hepatoma HepG2 cells as well as inhibitory activities against erastin-induced ferroptosis on human hepatoma Hep3B cells and IL-1β production from LPS-treated murine microglial cells.
从药用植物阿魏（伞形科）的根部的植物化学研究中分离出 20 种倍半萜，包括 12 种以前未描述的化合物，即 Dauferulins A-L（1-12）。详细的光谱分析表明 1-12 是具有 C-6 上对甲氧基苯甲酰氧基的大根香叶型倍半萜。通过 ECD 光谱分析推断出 1-12 的绝对构型。Dauferulins A-L（1-12）、已知的倍半萜（13-20）和从 6-O-对甲氧基苯甲酰-10α-当归酰氧基-杰斯坎迪醇（14）衍生的类似物（14a-14l）被评估了它们对人肝癌 HepG2 细胞中 AMPK 磷酸化的影响，以及对人肝癌 Hep3B 细胞中 erastin 诱导的铁死亡的抑制活性和 LPS 处理的鼠小胶质细胞中 IL-1β 的产生。
