Development of Fisheries, Faculty of Marine Science and Technology, Tokai University.
Department of Health and Nutrition, Faculty of Human Life Studies, University of Niigata Prefecture.
J Nutr Sci Vitaminol (Tokyo). 2024;70(1):19-24. doi: 10.3177/jnsv.70.19.
In this study, we investigated the effects of a porcine liver protein hydrolysate (PLH) diet on lipid metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type II diabetes. OLETF rats (20-wk-old males) were pair-fed with either a PLH diet containing 20% PLH or a casein diet for 14 wk. Dietary PLH significantly lowered serum cholesterol and phospholipid concentrations, mainly by decreasing low-density lipoprotein and high-density lipoprotein fractions. Fecal cholesterol was significantly increased in the PLH diet group; however, the total bile acid concentration in the feces was not significantly different between the groups. In addition, the PLH diet significantly decreased serum thiobarbituric acid reactive substance concentrations. These results suggest that dietary PLH exerts hyperlipidemic and antioxidant effects, indicating that it is a novel functional food ingredient.
在这项研究中，我们研究了猪肝蛋白水解物（PLH）饮食对 2 型糖尿病模型 Otuska Long-Evans Tokushima Fatty（OLETF）大鼠脂代谢的影响。OLETF 大鼠（20 周龄雄性）被配对喂食含有 20% PLH 的 PLH 饮食或酪蛋白饮食 14 周。饮食 PLH 显著降低了血清胆固醇和磷脂浓度，主要通过降低低密度脂蛋白和高密度脂蛋白分数。PLH 饮食组粪便中的胆固醇显著增加；然而，粪便中总胆汁酸浓度在两组之间没有显著差异。此外，PLH 饮食显著降低了血清硫代巴比妥酸反应物质浓度。这些结果表明，饮食 PLH 具有降血脂和抗氧化作用，表明它是一种新型的功能性食品成分。
