Shimizu Muneshige, Tanabe Soichi, Morimatsu Fumiki, Nagao Koji, Yanagita Teruyoshi, Kato Norihisa, Nishimura Toshihide
Research and Development Center, Nippon Meat Packers, Inc, Ibaraki, Japan.
Biosci Biotechnol Biochem. 2006 Jan;70(1):112-8. doi: 10.1271/bbb.70.112.
This study was performed to examine the effect of consumption of pork-liver protein hydrolysate (PLH) on body fat accumulation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats as a non-insulin-dependent diabetes mellitus model and in Long-Evans Tokushima Otsuka (LETO) rats as a control. Male 20-week-old OLETF and LETO rats were pair-fed either PLH or casein containing diet for 14 weeks. In the OLETF rats, dietary PLH significantly reduced the growth and weight of fat pad including perirenal and epididymal adipose tissues. Consumption of PLH markedly suppressed hepatic activities of lipogenesis enzymes such as glucose-6-phosphate dehydrogenase and fatty acid synthase and slightly elevated fecal excretion of total fat. In the LETO rats, growth and adipose tissue weight were unaffected by dietary treatment. The results suggest that PLH is a novel ingredient suppressing body fat in genetically obese rats by reducing lipogenesis.
本研究旨在考察食用猪肝蛋白水解物（PLH）对作为非胰岛素依赖型糖尿病模型的大冢长- Evans 德岛肥胖（OLETF）大鼠以及作为对照的长- Evans 德岛大冢（LETO）大鼠体脂积累的影响。20周龄雄性OLETF和LETO大鼠分别成对喂养含PLH或酪蛋白的饲料14周。在OLETF大鼠中，日粮中的PLH显著降低了包括肾周和附睾脂肪组织在内的脂肪垫的生长和重量。食用PLH显著抑制了脂肪生成酶如葡萄糖-6-磷酸脱氢酶和脂肪酸合酶的肝脏活性，并略微提高了总脂肪的粪便排泄量。在LETO大鼠中，日粮处理对生长和脂肪组织重量没有影响。结果表明，PLH是一种通过减少脂肪生成来抑制遗传性肥胖大鼠体脂的新型成分。
