Lazorthes Y, Verdie J C, Bastide R, Lavados A, Descouens D
Appl Neurophysiol. 1985;48(1-6):234-41. doi: 10.1159/000101133.
Early publications have separately reported the efficacy, specificity and conservative character of direct spinal and intraventricular morphine analgesia in the treatment of intractable cancer pain. The objectives of this study are to compare efficacy and safety of these sites of local administration in order to determine the indication for each, the clinical effects of different opiates and the choice of various drug administration devices.
早期的出版物分别报道了直接脊髓和脑室内注射吗啡镇痛在治疗顽固性癌痛方面的疗效、特异性和保守性。本研究的目的是比较这些局部给药部位的疗效和安全性，以确定每种给药部位的适应症、不同阿片类药物的临床效果以及各种给药装置的选择。
