Patterson V, Watt M, Byrnes D, Crowe D, Lee A
Department of Neurology, Royal Victoria Hospital, Belfast, UK.
J Neurol Neurosurg Psychiatry. 1994 May;57(5):582-5. doi: 10.1136/jnnp.57.5.582.
Intrathecal baclofen abolishes spasticity in many patients with neurological diseases but there are few studies on its long-term effectiveness. Since 1986 a manually operated subcutaneous pump has been used to deliver baclofen intrathecally in 21 patients with a follow up of at least one year. Most patients had multiple sclerosis and all were wheelchair-bound. Sixteen patients had a complete and sustained benefit. In four other patients the treatment was effective in the short term but not in the long term. In the remaining patient the pump never worked. Complications included meningitis, pump failure, erosion through the skin, and baclofen overdose. Nevertheless, only three patients have asked to discontinue the treatment. We conclude that intrathecal baclofen, delivered by a manually operated implanted pump, is an effective treatment for severe spasticity in most patients.
鞘内注射巴氯芬可消除许多神经系统疾病患者的痉挛状态，但关于其长期疗效的研究较少。自1986年以来，已使用手动皮下泵对21例患者进行鞘内注射巴氯芬治疗，随访时间至少1年。大多数患者患有多发性硬化症，且均需借助轮椅行动。16例患者获得了完全且持续的疗效。另外4例患者在短期内治疗有效，但长期无效。其余1例患者的泵从未发挥作用。并发症包括脑膜炎、泵故障、皮肤破溃以及巴氯芬过量。然而，只有3例患者要求停止治疗。我们得出结论，通过手动植入泵进行鞘内注射巴氯芬，对大多数患者的严重痉挛状态是一种有效的治疗方法。
