Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK; Institute of Health Sciences, University of O'Higgins, Santiago, Chile.
Trends Endocrinol Metab. 2024 Jul;35(7):638-647. doi: 10.1016/j.tem.2024.02.002. Epub 2024 Feb 28.
The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidative stress, and altered placental function. Here, we review recent research exploring the involvement of inflammation and oxidative stress as mechanisms impacting the placenta and fetus during obese pregnancy. Understanding them is crucial for informing strategies that can mitigate the adverse health effects of maternal obesity on offspring development and disease risk.
肥胖症的流行导致了大量研究，这些研究调查了母亲肥胖对怀孕和后代健康的影响。胎盘，传统上被视为母亲和胎儿之间的被动中介，已知在调节宫内环境和胎儿发育方面发挥着关键作用，我们现在知道母亲肥胖会导致炎症、氧化应激和胎盘功能改变增加。在这里，我们回顾了最近的研究，探讨了炎症和氧化应激作为影响肥胖妊娠期间胎盘和胎儿的机制的参与。了解这些机制对于制定减轻母亲肥胖对后代发育和疾病风险的不良健康影响的策略至关重要。
