Salehpoor Zahra, Rezapourmoghadam Mohamad, Tanideh Nader, Jahromi Maryam Koushkie
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran.
Stem Cells Technology Research Center, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Iran.
Eur J Obstet Gynecol Reprod Biol X. 2024 Feb 21;21:100292. doi: 10.1016/j.eurox.2024.100292. eCollection 2024 Mar.
This study evaluated the effects of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and pentoxifylline (PTX) on coagulation factors, including the amount and percentage of lymphocytes, PLC, PLR, aPTT, PT, PT.I.N. R in a model of rats with endometriosis.
Endometriosis was surgically induced in female Sprague-Dawley rats. The rats with confirmed endometrial implants were divided into control, MICT, pentoxifylline (D), HIIT+D, and MICT+D, HIIT groups. D and exercise interventions were performed for eight weeks. Then, the macroscopic size of endometriosis lesions was measured, and inflammatory factors (count and percentage of lymphocytes) and coagulation factors, including PLC, PLR, aPTT, PT, PT.I.N. R, and PLR in blood samples were evaluated.
D significantly decreased the volume of lesions and significantly increased PT and PT.I.N. R in blood. HIIT decreased the volume of lesions and significantly increased PT. MICT did not cause significant effects on the target variables. MICT+D decreased the volume of lesions. HIIT+D significantly decreased the volume of lesions and PLC and increased aPTT as well as the count and percentage of lymphocytes, PT, and PT.I.N. R, and decreased PLR.
All interventions(except for MICT) especially HIIT+D and D by priority, induced a significant effect on reducing some indices of inflammation and coagulation.
本研究评估了高强度间歇训练（HIIT）、中等强度持续训练（MICT）和己酮可可碱（PTX）对子宫内膜异位症大鼠模型凝血因子的影响，包括淋巴细胞数量和百分比、血小板计数（PLC）、血小板与淋巴细胞比值（PLR）、活化部分凝血活酶时间（aPTT）、凝血酶原时间（PT）、国际标准化比值（PT.IN.R）。
通过手术诱导雌性Sprague-Dawley大鼠患子宫内膜异位症。将确诊有子宫内膜植入物的大鼠分为对照组、MICT组、己酮可可碱组（D组）、HIIT+D组、MICT+D组和HIIT组。进行为期八周的D组药物及运动干预。然后，测量子宫内膜异位症病变的宏观大小，并评估炎症因子（淋巴细胞计数和百分比）以及血液样本中的凝血因子，包括PLC、PLR、aPTT、PT、PT.IN.R和PLR。
D组显著减小了病变体积，并显著提高了血液中的PT和PT.IN.R。HIIT减小了病变体积并显著提高了PT。MICT对目标变量未产生显著影响。MICT+D减小了病变体积。HIIT+D显著减小了病变体积和PLC，并提高了aPTT以及淋巴细胞计数和百分比、PT和PT.IN.R，同时降低了PLR。
所有干预措施（除MICT外），尤其是HIIT+D和优先考虑的D组，对降低一些炎症和凝血指标产生了显著效果。
