Keleş Didem Beşikci, Bilici Rabia, Ayık Batuhan, Kılıç Muhsin Koray, Kliewer Wendy
Department of Psychiatry, Erenkoy Mental and Nervous Diseases Training and Research Hospital, Istanbul, Erenkoy, Turkey.
Department of Psychology, Virginia Commonwealth University (VCU), Richmond VA, US.
Indian J Psychiatry. 2024 Jan;66(1):90-97. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_520_23. Epub 2024 Jan 25.
Opioid use disorders (OUDs) affect over 16 million people worldwide, with a particularly high prevalence rate in Asia. OUDs are associated with significant health consequences, including neurocognitive impairment, which affects individuals' ability to make decisions, respond to stressful situations, and regulate behavior. Understanding the specific ways in which OUDs affect cognitive functioning is important in treatment considerations.
This study compared the attention, impulsivity, and executive functions of Turkish men with active OUD ( = 40) with those of men in remission from OUD who were on buprenorphine/naloxone maintenance (BMT; = 41) and with those of a comparison group of healthy controls (HC; = 43). The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess neurocognitive functioning.
Analyses found significant impairment in measures of continuous attention, cognitive impulsivity, motor impulsivity, and executive functions in the two patient groups compared to the control group, but the two patient groups did not differ from each other.
The data from this study indicate that individuals with OUD exhibit neurocognitive damage, and those in remission from OUD who receive maintenance treatment do not show improvement in this domain. Neurocognitive damages should be considered in long-term treatment planning of patients with OUD.
阿片类物质使用障碍（OUDs）在全球影响着超过1600万人，在亚洲的患病率尤其高。OUDs会带来严重的健康后果，包括神经认知障碍，这会影响个体做出决策、应对压力情况和调节行为的能力。了解OUDs影响认知功能的具体方式对于治疗考量非常重要。
本研究比较了患有活跃型OUD的土耳其男性（n = 40）、接受丁丙诺啡/纳洛酮维持治疗（BMT；n = 41）且处于OUD缓解期的男性以及健康对照组（HC；n = 43）的注意力、冲动性和执行功能。使用剑桥神经心理测试自动成套系统（CANTAB）评估神经认知功能。
分析发现，与对照组相比，两个患者组在持续注意力、认知冲动性、运动冲动性和执行功能的测量指标上存在显著损害，但两个患者组之间没有差异。
本研究的数据表明，患有OUD的个体存在神经认知损伤，接受维持治疗且处于OUD缓解期的个体在这方面并未显示出改善。在OUD患者的长期治疗规划中应考虑神经认知损伤。
