Han Xiaoqing, Bi Luopeng, Yan Jiao, Song Panpan, Wang Yanjing, Wang Xingbo, Wu Yunyun, Ding Xiaobo, Zhang Haiyuan, Wang Yanbo, Li Xi
Department of Urology, First Hospital of Jilin University, Changchun, 130021, China.
Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Mater Today Bio. 2024 Feb 16;25:101002. doi: 10.1016/j.mtbio.2024.101002. eCollection 2024 Apr.
Acute kidney injury (AKI) is a heterogeneous, high-mortality clinical syndrome with diverse pathogenesis and prognosis, but it lacks the effective therapy clinically. Its pathogenesis is associated with production of reactive oxygen/nitrogen species and infiltration of inflammatory cells. To overcome these pathogenic factors and improve the therapeutic efficiency, we synthesized triptolide-loaded mesoscale polydopamine melanin-mimetic nanoparticles (MeNP) as the antioxidant plus anti-inflammatory therapeutic platform to synergistically scavenge reactive oxygen/nitrogen species (RONS), inhibit the activity of macrophages and dendritic cells, and generate Treg cells for AKI therapy. It was demonstrated that mesoscale size was beneficial for MeNP to specifically accumulate at renal tubule cells, and MeNP could significantly attenuate oxidative stress, reduce proinflammatory immune cells in renal, and repair renal function in cisplatin-induced AKI mouse model. MeNP might be a potential candidate to inhibit oxidative damages and inflammatory events in AKI.
急性肾损伤（AKI）是一种异质性、高死亡率的临床综合征，其发病机制和预后各不相同，但临床上缺乏有效的治疗方法。其发病机制与活性氧/氮物种的产生以及炎症细胞的浸润有关。为了克服这些致病因素并提高治疗效果，我们合成了负载雷公藤甲素的介观尺度聚多巴胺黑色素模拟纳米颗粒（MeNP）作为抗氧化加抗炎治疗平台，以协同清除活性氧/氮物种（RONS），抑制巨噬细胞和树突状细胞的活性，并生成调节性T细胞用于AKI治疗。结果表明，介观尺度有利于MeNP特异性积聚在肾小管细胞，并且MeNP可以显著减轻顺铂诱导的AKI小鼠模型中的氧化应激，减少肾脏中的促炎免疫细胞，并修复肾功能。MeNP可能是抑制AKI氧化损伤和炎症事件的潜在候选物。
