Maxillofacial Surgery Operative Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
PhD School of Biomedical Sciences, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Acta Otorhinolaryngol Ital. 2024 Feb;44(1):42-51. doi: 10.14639/0392-100X-N2736.
To translate and validate an Italian version of the Questionnaire of Olfactory Disorders (IT-QOD).
This is a prospective, multicentre study that involved patients with olfactory dysfunction (OD). Both cases and controls underwent administration of the IT-QOD, Sino-Nasal Outcome Test-22 (SNOT-22) and psychophysical evaluation of orthonasal and retronasal olfactory function.
The IT-QOD was administered to 96 patients and 38 controls. The Cronbach's alpha exceeded 0.90, indicating satisfactory internal consistency. The test-retest reliability was found to be high for both parosmia (rs = 0.944) and life quality (rs = 0.969). Patients with OD had significantly higher IT-QOD scores compared to healthy individuals (p < 0.001), indicating strong internal validity. The external validity was also satisfactory, as shown by the significant correlation with SNOT-22 (rs = -0.54) and the threshold, discrimination, and identification score (rs = -0.63).
The IT-QOD was demonstrated to be reliable and valid to assess the impact of OD on the quality of life of Italian-speaking patients.
翻译和验证嗅觉障碍问卷（意大利语版，IT-QOD）。
这是一项前瞻性、多中心研究，纳入嗅觉功能障碍（OD）患者。病例组和对照组均接受 IT-QOD、鼻-鼻窦结局测试 22 项（SNOT-22）和鼻前、鼻后嗅觉功能的心理物理评估。
共纳入 96 例患者和 38 例对照组。Cronbach's α 值大于 0.90，表明内部一致性良好。嗅觉异常和生活质量的重测信度均较高（rs = 0.944 和 rs = 0.969）。OD 患者的 IT-QOD 评分明显高于健康对照组（p < 0.001），表明具有较强的内部有效性。与 SNOT-22（rs = -0.54）和嗅觉阈值、辨别和识别评分（rs = -0.63）显著相关，表明具有良好的外部有效性。
IT-QOD 具有良好的可靠性和有效性，可用于评估意大利语患者 OD 对生活质量的影响。
