新冠病毒感染者持续性嗅觉障碍的患病率：一项为期 1 年随访的心理物理学病例对照研究。
Prevalence of Persistent Olfactory Disorders in Patients With COVID-19: A Psychophysical Case-Control Study With 1-Year Follow-up.
机构信息
Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Biomedical Science PhD School, Biomedical Science Department, University of Sassari, Sassari, Italy.
出版信息
Otolaryngol Head Neck Surg. 2022 Jul;167(1):183-186. doi: 10.1177/01945998211061511. Epub 2021 Nov 23.
The purpose of this multicenter case-control study was to evaluate a group of patients at least 1 year after coronavirus disease 2019 (COVID-19) with Sniffin' Sticks tests and to compare the results with a control population to quantify the potential bias introduced by the underlying prevalence of olfactory dysfunction (OD) in the general population. The study included 170 cases and 170 controls. In the COVID-19 group, 26.5% of cases had OD (anosmia in 4.7%, hyposmia in 21.8%) versus 3.5% in the control group (6 cases of hyposmia). The TDI score (threshold, discrimination, and identification) in the COVID-19 group was significantly lower than in the control group (32.5 [interquartile range, 29-36.5] vs 36.75 [34-39.5], < .001). The prevalence of OD was significantly higher in the COVID-19 group, confirming that this result is not due to the underlying prevalence of OD in the general population.
这项多中心病例对照研究的目的是用 Sniffin' Sticks 测试评估 COVID-19 后至少 1 年的一组患者，并将结果与对照组进行比较，以量化一般人群中嗅觉功能障碍 (OD) 的潜在流行率所带来的偏差。该研究纳入了 170 例病例和 170 例对照。在 COVID-19 组中，26.5%的病例存在 OD（无嗅觉 4.7%，嗅觉减退 21.8%），而对照组为 3.5%（6 例嗅觉减退）。COVID-19 组的 TDI 评分（阈值、辨别和识别）明显低于对照组（32.5 [四分位间距，29-36.5] vs 36.75 [34-39.5]，<.001）。COVID-19 组的 OD 患病率明显更高，证实这一结果并非归因于一般人群中 OD 的潜在流行率。
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