Advent Health Sebring, Sebring, Florida, USA.
Clin Anat. 2024 Jul;37(5):505-521. doi: 10.1002/ca.24147. Epub 2024 Feb 29.
Hyperostosis frontalis interna (HFI) is a condition defined as abnormal bone growth on the posterior aspect of the frontal bone. Despite uncertainties regarding its etiology and prognosis, clinicians typically consider HFI a benign pathology. There are no studies organizing all the possible manifestations of the disease. The present study aims to organize all the clinical manifestations of HFI within the current case report/series literature. A blinded PRISMA-guided search of HFI case reports and case series yielded 43 relevant articles and provided 110 patients for analysis. The symptoms presenting alongside HFI were extracted and tabulated. We found high-frequency clinical manifestations of HFI (>20% of patients) to include headaches, obesity, vertigo/dizziness symptoms, cognitive decline, and depression. An additional 15 symptoms were tabulated at frequencies found to be less than 20%. Based on our analysis, we suggest the constellation of high-frequency symptoms can offer a more comprehensive clinical picture of symptomatic HFI which may be valuable to consider for clinicians and future researchers in the field of HFI.
颅内骨肥厚症（HFI）是一种定义为额骨后表面异常骨生长的病症。尽管其病因和预后存在不确定性，但临床医生通常认为 HFI 是一种良性病变。目前还没有研究对该疾病的所有可能表现进行分类。本研究旨在对当前病例报告/系列文献中 HFI 的所有临床表现进行组织。一项针对 HFI 病例报告和病例系列的盲法 PRISMA 指导搜索产生了 43 篇相关文章，并为分析提供了 110 名患者。提取并列出了与 HFI 同时出现的症状。我们发现 HFI 的高频临床表现（>20%的患者）包括头痛、肥胖、眩晕/头晕症状、认知能力下降和抑郁。另外 15 种症状的出现频率低于 20%。基于我们的分析，我们建议高频症状组合可以提供更全面的有症状 HFI 临床图片，这对于 HFI 领域的临床医生和未来的研究人员可能具有重要价值。
