Pockle Rachana, Masareddy Rajashree, Bambulkar Vijay, Desai Rishabh, Kiran Sai
Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education & Research, Nehru Nagar, Belagavi - 590010, Karnataka, India.
Koel Colors, Pvt. Ltd., Mumbai, India.
Ther Deliv. 2024 Apr;15(4):253-266. doi: 10.4155/tde-2023-0101. Epub 2024 Feb 29.
To explore 'magnesium myristate' for its dual functionality as a lubricant and binder in the formulation of tablets. Using (DoE), tablet formulations using magnesium myristate and conventional excipients (magnesium stearate and PVP K30) were developed by wet granulation technique. The prepared granules and formulated tablets were evaluated for pre- and post-compression parameters, respectively. Magnesium myristate exhibited excellent flow properties. The optimized formulations containing magnesium myristate exhibited increased hardness and drug release in comparison to conventional excipients. similarity index for drug release showed no significant variations with optimized formulations and with the marketed formulations. Magnesium myristate shows a promising replacement for conventional excipients as both a lubricant and binder in tablet formulation.
探索肉豆蔻酸镁在片剂配方中作为润滑剂和粘合剂的双重功能。采用实验设计（DoE），通过湿法制粒技术开发了使用肉豆蔻酸镁和传统辅料（硬脂酸镁和聚乙烯吡咯烷酮K30）的片剂配方。分别对制备的颗粒和制成的片剂进行了压片前和压片后的参数评估。肉豆蔻酸镁表现出优异的流动性能。与传统辅料相比，含有肉豆蔻酸镁的优化配方表现出更高的硬度和药物释放度。药物释放的相似性指数在优化配方和市售配方之间没有显著差异。肉豆蔻酸镁在片剂配方中作为润滑剂和粘合剂显示出有望替代传统辅料的前景。
