Universidade Tiradentes - UNIT, Programa de Pós-graduação em Saúde e Ambiente, Aracaju, SE, Brasil.
Universidade Tiradentes - UNIT, Curso de Biomedicina, Aracaju, SE, Brasil.
Braz J Biol. 2024 Feb 26;83:e275439. doi: 10.1590/1519-6984.275439. eCollection 2024.
Visceral Leishmaniasis is included among the neglected tropical diseases, being directly related to conditions of social vulnerability, in urban environments, dogs act as important reservoirs. The aim of the study was to evaluate the distribution of dogs, related risk factors and identify of volatile organic compounds from infected dogs. Peripheral blood samples from 72 dogs were collected for detection using the ELISA test, in addition to hair samples for analysis by GC-MS. Of the evaluated dogs, 13 (18.05%/72) were reactive for canine VL, seven in Aracaju and six in Propriá. Factors related to vegetation, age, place where the dog stays and free access to the street, were associated with a greater chance of the dog becoming infected. Fifty-three compounds were identified from ten canine hair samples, among which 2-butoxyethanol, benzaldehyde, decane, 2-phenylacetaldehyde, nonan-1-ol, 2-phenoxyethanol, nonanoic acid, 8-heptadecene and eicosane were found in seropositive dogs for leishmaniasis. The guardian's posture has been increasingly important, requiring more attention to the dog's health and actions aimed at environmental management in an attempt to reduce cases of canine VL in the state. Even though the identified VOCs have not been associated with leishmanial infection, it is of great use for understanding canine hair substances.
内脏利什曼病被列入被忽视的热带病，与城市环境中的社会脆弱性条件直接相关，在城市环境中，狗是重要的储存宿主。本研究旨在评估狗的分布、相关危险因素，并鉴定感染狗的挥发性有机化合物。采集了 72 只狗的外周血样本进行 ELISA 检测，同时采集毛发样本进行 GC-MS 分析。在评估的狗中，有 13 只（18.05%/72）对犬内脏利什曼病呈反应性，其中 7 只在阿拉卡茹，6 只在普拉波阿。与植被、年龄、狗居住的地方以及是否可以自由出入街道有关的因素与狗感染的可能性更大有关。从 10 只犬毛发样本中鉴定出 53 种化合物，其中 2-丁氧基乙醇、苯甲醛、癸烷、2-苯乙醛、壬醇、2-苯氧基乙醇、壬酸、8-十七烯和二十烷在利什曼病血清阳性犬中被发现。监护人的态度越来越重要，需要更加关注狗的健康和针对环境管理的措施，以试图减少该州的犬内脏利什曼病病例。尽管鉴定出的 VOCs 与利什曼原虫感染无关，但它们对于了解犬毛中的物质非常有用。
