Anses, Laboratory for Animal Health in Normandy, Physiopathology and Epidemiology of Equine Diseases Unit, 14430 Goustranville, France; Mixed Technological Unit "Equine Health and Welfare - Organisation and Traceability of the Equine Industry" (UMT SABOT), France.
Anses, Laboratory for Animal Health in Normandy, Physiopathology and Epidemiology of Equine Diseases Unit, 14430 Goustranville, France; Mixed Technological Unit "Equine Health and Welfare - Organisation and Traceability of the Equine Industry" (UMT SABOT), France.
Int J Parasitol Drugs Drug Resist. 2024 Apr;24:100528. doi: 10.1016/j.ijpddr.2024.100528. Epub 2024 Feb 23.
This study assessed the anthelmintic resistance in strongylid nematodes against commonly used anthelmintic (AH) drugs in a French galloping racehorse stud farm from March to December 2023. Faecal egg count reduction tests (FECRTs) were conducted in three different groups of Thoroughbred yearlings (a group of 6 males, a group of 13 females and a group of 8 females and 3 males) following the new World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines. The efficacy of fenbendazole was tested in two groups once during the monitoring period (in March), the efficacy of ivermectin in 3 groups twice (in March-April and in November-December) and the efficacy of pyrantel in one group once (in May-June). For each FECRT, the 90% confidence interval of the percentage faecal egg count reduction was calculated using the hybrid Frequentist/Bayesian analysis method. The resistance in strongylids was observed to fenbendazole, pyrantel and ivermectin in all the groups in which these drugs were tested. The number of animals in each group was sufficient to reach ≥80% power for the resistance test. The results highlight the first case of triple AH resistance in strongylids in France. Further studies involving more farms and equids are required to assess the prevalence of AH resistance in France and refine recommendations for owners.
本研究于 2023 年 3 月至 12 月在法国赛马育马场评估了马副蛔虫对常用驱虫（AH）药物的抗药性。根据新的世界兽医寄生虫学协会（WAAVP）指南，对三组不同的纯种幼马（一组 6 匹公马、一组 13 匹母马和一组 8 匹母马和 3 匹公马）进行了粪便卵计数减少试验（FECRT）。在监测期间（3 月），芬苯达唑在两组中进行了一次药效测试，伊维菌素在三组中进行了两次药效测试（3 月至 4 月和 11 月至 12 月），并在一组中进行了一次吡喹酮药效测试（5 月至 6 月）。对于每次 FECRT，使用混合频率派/Bayesian 分析方法计算粪便卵计数减少率的 90%置信区间。在所有接受这些药物测试的组中，均观察到马副蛔虫对芬苯达唑、吡喹酮和伊维菌素的耐药性。每组的动物数量足以达到抗药性测试的≥80%功效。结果突显了法国首例马副蛔虫三重 AH 耐药性的情况。需要进一步开展涉及更多农场和马的研究，以评估法国 AH 耐药性的流行情况，并为所有者提供更精确的建议。
