Molecular Aging & Development Laboratory, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Boston University Photonics Center, Boston University, Boston, MA, USA; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Molecular Aging & Development Laboratory, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Boston University Photonics Center, Boston University, Boston, MA, USA; Department of Biomedical Engineering, Boston University, Boston, MA, USA; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA.
Exp Eye Res. 2024 Apr;241:109818. doi: 10.1016/j.exer.2024.109818. Epub 2024 Feb 2.
Down syndrome (DS) is the most common chromosomal disorder in humans. DS is associated with increased prevalence of several ocular sequelae, including characteristic blue-dot cerulean cataract. DS is accompanied by age-dependent accumulation of Alzheimer's disease (AD) amyloid-β (Aβ) peptides and amyloid pathology in the brain and comorbid early-onset Aβ amyloidopathy and colocalizing cataracts in the lens. Quasi-elastic light scattering (QLS) is an established optical technique that noninvasively measures changes in protein size distributions in the human lens in vivo. In this cross-sectional study, lenticular QLS correlation time was decreased in adolescent subjects with DS compared to age-matched control subjects. Clinical QLS was consistent with alterations in relative particle hydrodynamic radius in lenses of adolescents with DS. These correlative results suggest that noninvasive QLS can be used to evaluate molecular changes in the lenses of individuals with DS.
唐氏综合征（DS）是人类最常见的染色体疾病。DS 与多种眼部后遗症的发病率增加有关，包括特征性的蓝点天青石白内障。DS 伴有年龄依赖性的阿尔茨海默病（AD）淀粉样β（Aβ）肽和脑内淀粉样病理学的积累，以及晶状体中早发性 Aβ淀粉样变和共定位白内障的合并症。准弹性光散射（QLS）是一种成熟的光学技术，可非侵入性地测量活体人眼中蛋白质大小分布的变化。在这项横断面研究中，与年龄匹配的对照组相比，DS 青少年受试者的晶状体 QLS 相关时间缩短。临床 QLS 与 DS 青少年晶状体中相对颗粒流体力学半径的改变一致。这些相关结果表明，非侵入性 QLS 可用于评估 DS 个体晶状体中的分子变化。
