Olsson L, Behnke O
Cancer Surv. 1985;4(2):421-38.
The cellular origin of the malignant cells in Hodgkin's disease (HD) has been discussed for several decades. Previous investigations on fresh biopsy material and cultured cells from lesions of Hodgkin's disease have led to various suggestions such as a T lymphocyte, B lymphocyte or monocyte/macrophage origin of HD cells. However, all these studies have been hampered by uncertainty in the identification of the truly malignant cells. It has therefore been desirable to establish in vitro lines of the malignant cell population in HD. A number of cell lines from HD lesions has been described, but most of these studies can, upon a critical appraisal, be dismissed as not being representative for Hodgkin's and Reed-Sternberg cells. We report on the phenotypes of established cell lines of Hodgkin's cells and conclude that it is most likely that the malignant Hodgkin's cells are derived from cells of the monocyte/macrophage lineage.
几十年来，人们一直在讨论霍奇金淋巴瘤（HD）中恶性细胞的细胞起源。此前对霍奇金淋巴瘤病变的新鲜活检材料和培养细胞的研究提出了各种观点，例如HD细胞起源于T淋巴细胞、B淋巴细胞或单核细胞/巨噬细胞。然而，所有这些研究都因难以确定真正的恶性细胞而受到阻碍。因此，建立HD恶性细胞群体的体外细胞系是很有必要的。已有多项研究描述了来自HD病变的细胞系，但经严格评估，其中大多数研究都不能被视为代表霍奇金细胞和里德-斯腾伯格细胞。我们报告了已建立的霍奇金细胞系的表型，并得出结论，恶性霍奇金细胞很可能起源于单核细胞/巨噬细胞谱系的细胞。
