脊髓损伤：新兴技术

Spinal Cord Injury: Emerging Technologies.

作者信息

Hersh Andrew M, Weber-Levine Carly, Jiang Kelly, Theodore Nicholas

机构信息

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 7-113, Baltimore, MD 21287, USA. Electronic address: https://twitter.com/AndrewMHersh.

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 7-113, Baltimore, MD 21287, USA.

出版信息

Neurosurg Clin N Am. 2024 Apr;35(2):243-251. doi: 10.1016/j.nec.2023.10.001. Epub 2023 Nov 10.

DOI:10.1016/j.nec.2023.10.001

PMID:38423740

Abstract

The mainstay of treatment for spinal cord injury includes decompressive laminectomy and elevation of mean arterial pressure. However, outcomes often remain poor. Extensive research and ongoing clinical trials seek to design new treatment options for spinal cord injury, including stem cell therapy, scaffolds, brain-spine interfaces, exoskeletons, epidural electrical stimulation, ultrasound, and cerebrospinal fluid drainage. Some of these treatments are targeted at the initial acute window of injury, during which secondary damage occurs; others are designed to help patients living with chronic injuries.

摘要

脊髓损伤的主要治疗方法包括减压性椎板切除术和平均动脉压升高。然而，治疗结果往往仍然很差。广泛的研究和正在进行的临床试验试图为脊髓损伤设计新的治疗方案，包括干细胞疗法、支架、脑-脊髓接口、外骨骼、硬膜外电刺激、超声波和脑脊液引流。其中一些治疗针对损伤后的初始急性窗口期，在此期间会发生继发性损伤；其他治疗则旨在帮助患有慢性损伤的患者。