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用于治疗掌跖多汗症的A型和B型肉毒杆菌毒素

Botulinum Toxin A and B for Palmoplantar Hyperhidrosis.

作者信息

Eilertsen Trond, Kvammen Bjørn Øivind, Grimstad Øystein

机构信息

Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

Department of Dermatology, University Hospital of North Norway, Tromsø, Norway.

出版信息

Dermatol Ther (Heidelb). 2024 Mar;14(3):805-811. doi: 10.1007/s13555-024-01113-3. Epub 2024 Mar 1.

DOI:10.1007/s13555-024-01113-3
PMID:38424385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10965841/
Abstract

INTRODUCTION

Hyperhidrosis is characterized by unpredictable, uncontrollable and excessive sweating. It occurs at rest and is not related to temperature. Hyperhidrosis is a common disorder that has a negative impact on quality of life (QoL). The aim of this quality assurance study was to investigate how treatment of palmoplantar hyperhidrosis with botulinum toxin A (BTX-A) and botulinum toxin B (BTX-B) led to improvement of patient reported outcome measures related to QoL.

METHODS

A total of 35 patients with palmar and/or plantar hyperhidrosis who had received BTX-A (Dysport) and BTX-B (NeuroBloc) for palmar hyperhidrosis and BTX-B for plantar hyperhidrosis were included in this study. In total, palms were injected with a median dose (low to high) of 400 (100-550) units BTX-A and a median dose (low to high) of 200 (200-500) units. BTX-B was used in the thenar and hypothenar areas to avoid muscle weakness. In the soles a total median dose (low to high) of 600 (475-1000) units BTX-B was injected.

RESULTS

At follow-up 2 weeks post-treatment, patients' Dermatology Life Quality Index (DLQI) score improved from 13 to 2 (p < 0.001).

CONCLUSION

We found that BTX-A and BTX-B treatment for palmar hyperhidrosis and BTX-B treatment for plantar hyperhidrosis led to a substantial improvement of QoL.

摘要

引言

多汗症的特点是出汗不可预测、无法控制且过多。它在休息时发生，与温度无关。多汗症是一种常见疾病，会对生活质量（QoL）产生负面影响。这项质量保证研究的目的是调查用A型肉毒杆菌毒素（BTX-A）和B型肉毒杆菌毒素（BTX-B）治疗掌跖多汗症如何改善与生活质量相关的患者报告结局指标。

方法

本研究纳入了35例手掌和/或足底多汗症患者，他们接受了用于治疗手掌多汗症的BTX-A（Dysport）和BTX-B（NeuroBloc）以及用于治疗足底多汗症的BTX-B。总共向手掌注射了中位剂量（低至高）的400（100 - 550）单位BTX-A和中位剂量（低至高）的200（200 - 500）单位。在大鱼际和小鱼际区域使用BTX-B以避免肌肉无力。在足底总共注射了中位剂量（低至高）的600（475 - 1000）单位BTX-B。

结果

在治疗后2周的随访中，患者的皮肤病生活质量指数（DLQI）评分从13分提高到2分（p < 0.001）。

结论

我们发现，BTX-A和BTX-B治疗手掌多汗症以及BTX-B治疗足底多汗症可使生活质量得到显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee56/10965841/804989065522/13555_2024_1113_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee56/10965841/97859414eec0/13555_2024_1113_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee56/10965841/804989065522/13555_2024_1113_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee56/10965841/97859414eec0/13555_2024_1113_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee56/10965841/804989065522/13555_2024_1113_Fig2_HTML.jpg

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The etiology, diagnosis, and management of hyperhidrosis: A comprehensive review: Etiology and clinical work-up.多汗症的病因、诊断和治疗：全面综述：病因和临床评估。
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